{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:44:12Z","timestamp":1791971052456,"version":"4.3.4"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Perivascular epithelioid cell tumours (PEComas) are rare mesenchymal neoplasms with characteristic myomelanocytic differentiation and limited descriptions in fine\u2010needle aspiration (FNA) specimens. A woman in her 30s with a history of ALK\u2010positive anaplastic large cell lymphoma in remission was found to have a 2.1\u2010cm hepatic mass during evaluation of persistent liver function abnormalities. Ultrasound\u2010guided FNA demonstrated a cellular neoplasm composed of loosely cohesive clusters and singly dispersed epithelioid to spindle cells with abundant eosinophilic cytoplasm, mild to moderate nuclear atypia and prominent nucleoli. Immunohistochemical studies showed positivity for smooth muscle actin, caldesmon, HMB\u201045 and Melan\u2010A, supporting a myomelanocytic phenotype. Molecular testing identified pathogenic TSC2 splice\u2010site mutations. Subsequent resection confirmed hepatic PEComa, epithelioid angiomyolipoma variant. This case highlights the characteristic cytomorphologic, immunophenotypic and molecular features of hepatic PEComa and demonstrates the value of FNA with ancillary testing in establishing a preoperative diagnosis and excluding morphologic mimics.<\/jats:p>","DOI":"10.1111\/cyt.70138","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:44:19Z","timestamp":1791967459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytomorphologic Features of Hepatic\n                    <scp>PEComa<\/scp>\n                    Diagnosed by Fine\u2010Needle Aspiration Biopsy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4460-7260","authenticated-orcid":false,"given":"Timothy","family":"Ramseyer","sequence":"first","affiliation":[{"name":"Department of Pathology University of Oklahoma Medical Center  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2639-8709","authenticated-orcid":false,"given":"Kyle","family":"Hinz","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4751-7678","authenticated-orcid":false,"given":"Ivy","family":"John","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7523-3437","authenticated-orcid":false,"given":"Parmjeet","family":"Randhawa","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5670-6254","authenticated-orcid":false,"given":"Samer","family":"Khader","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2020.09.006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000173232.22117.37"},{"key":"e_1_2_11_4_1","volume-title":"WHO Classification of Tumours: Soft Tissue and Bone Tumours","author":"WHO Classification of Tumours Editorial 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