{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:57:35Z","timestamp":1773885455098,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,27]],"date-time":"2013-01-27T00:00:00Z","timestamp":1359244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction and Aims<\/jats:title><jats:p>Concern about the non\u2010medical use of quetiapine and related acute harms is growing. Case series cite quetiapine as a potential drug of misuse, while recent research questions its relative safety in comparison with other atypical antipsychotic preparations. This paper explores population\u2010level patterns of quetiapine\u2010related ambulance attendances over time, identifying associated risk factors and potential subpopulations at\u2010risk of acute harms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>A retrospective analysis of quetiapine\u2010, olanzapine\u2010 and risperidone\u2010related ambulance attendances in metropolitan <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>elbourne and prescription data in <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>ictoria, <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia. Trends in ambulance attendance and prescription rates, attendance characteristics, and associated risk factors were explored from 2001 to 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Quetiapine was consistently associated with substantially higher rates of ambulance attendances relative to prescription availability than olanzapine or risperidone. Quetiapine prescribing rates increased at a significantly greater magnitude than olanzapine or risperidone, leading to substantial increases in quetiapine attendances by population. Quetiapine\u2010related attendances were associated with concurrent heroin and opioid replacement therapy toxicity, history of heroin and alcohol misuse, mood disorders, low <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lasgow <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>oma <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale and women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>Trends in quetiapine\u2010related ambulance attendances indicate rising community\u2010level harms and greater harm relative to other atypical antipsychotics, while prescription patterns suggest increasing quetiapine availability. The association of quetiapine\u2010related attendances with concurrent heroin and opioid replacement therapy toxicity as well as previous heroin and alcohol misuse suggest illicit and poly\u2010drug users are a subpopulation at greater risk of quetiapine\u2010related harms, consistent with emerging evidence of the use, misuse and diversion of quetiapine. <jats:italic>[Heilbronn C, Lloyd B, McElwee P, Eade A, Lubman DI. Trends in quetiapine use and non\u2010fatal quetiapine\u2010related ambulance attendances.<\/jats:italic> Drug Alcohol Rev <jats:italic>2013;32:405\u2013411<\/jats:italic>]<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.12028","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T03:22:36Z","timestamp":1359343356000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Trends in quetiapine use and non\u2010fatal quetiapine\u2010related ambulance attendances"],"prefix":"10.1111","volume":"32","author":[{"given":"Cherie","family":"Heilbronn","sequence":"first","affiliation":[{"name":"Turning Point Alcohol and Drug Centre, Eastern Health  Melbourne Australia"},{"name":"Eastern Health Clinical School Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Turning Point Alcohol and Drug Centre, Eastern Health  Melbourne Australia"},{"name":"Eastern Health Clinical School Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"McElwee","sequence":"additional","affiliation":[{"name":"Turning Point Alcohol and Drug Centre, Eastern Health  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Eade","sequence":"additional","affiliation":[{"name":"Ambulance Victoria  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan I.","family":"Lubman","sequence":"additional","affiliation":[{"name":"Turning Point Alcohol and Drug Centre, Eastern Health  Melbourne Australia"},{"name":"Eastern Health Clinical School Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,27]]},"reference":[{"issue":"1","key":"e_1_2_6_2_1","article-title":"Quetiapine versus other atypical antipsychotics for schizophrenia","author":"Komossa K","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000967.pub2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0401"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709990344"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.7.7.841"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00048670903489890"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10401230701866870"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867411432213"},{"key":"e_1_2_6_10_1","first-page":"13","article-title":"Is seroquel developing an illicit reputation for misuse\/abuse?","volume":"7","author":"Sansone RA","year":"2010","journal-title":"Psychiatry (Edgmont)"},{"key":"e_1_2_6_11_1","first-page":"167","article-title":"Quetiapine in substance use disorders, abuse and dependence possibility: a review","volume":"21","author":"Erdogan S","year":"2010","journal-title":"Turk Psikiyatri Derg"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.164.2.350"},{"key":"e_1_2_6_13_1","volume-title":"Licit and illicit quetiapine use among IDRS participants. 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