{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:54:24Z","timestamp":1781020464326,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T00:00:00Z","timestamp":1389830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction and Aims<\/jats:title><jats:p>Methadone maintenance treatment and buprenorphine maintenance treatment are the two main therapeutic options considered for opioid replacement therapy. This study was conducted to examine the effectiveness of methadone maintenance treatment and buprenorphine maintenance treatment in <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ran under usual clinical conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>In this outcome research, 311 patients consented to participate in the study (77.8% response rate). The <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>pioid <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reatment <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex, <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>eneral <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire and <jats:styled-content style=\"fixed-case\">WHOQOL\u2010BREF<\/jats:styled-content> questionnaire were used to assess the effectiveness of the therapeutic programs. Drop\u2010out rate was calculated after two and six months of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean dose of methadone was in an acceptable range; however, doses for buprenorphine maintenance treatment patients seemed low. The rates of attrition after two and six months of treatment were 24.2% and 44.0% in the methadone maintenance treatment group and 41.3% and 65.4% in the buprenorphine maintenance treatment group, respectively (<jats:italic>P<\/jats:italic>\u2009<jats:italic>&lt;<\/jats:italic>\u20090.001). Drug use, <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> risk\u2010taking behaviour, and mental and physical health improved in both groups at six months of treatment, while quality of life improved only in the methadone maintenance treatment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>The retention seen in the buprenorphine group may in part be related to the low buprenorphine doses used. As a whole, the positive results provide support to continuation of maintenance programs. <jats:italic>[Esmaeili H\u2010R, Ziaddinni H, Nikravesh M\u2010R, Baneshi M\u2010R, Nakhaee N. Outcome evaluation of the opioid agonist maintenance treatment in Iran. Drug Alcohol Rev 2014;33:186\u2013193]<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.12112","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T11:56:13Z","timestamp":1389873373000},"page":"186-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Outcome evaluation of the opioid agonist maintenance treatment in <scp>I<\/scp>ran"],"prefix":"10.1111","volume":"33","author":[{"given":"Hamid\u2010Reza","family":"Esmaeili","sequence":"first","affiliation":[{"name":"Research Center for Health Services Management Institute of Futures Studies in Health Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Ziaddinni","sequence":"additional","affiliation":[{"name":"Research Center for Social Determinants of Health Institute of Futures Studies in Health Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad\u2010Rafee","family":"Nikravesh","sequence":"additional","affiliation":[{"name":"Physiology Research Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad\u2010Reza","family":"Baneshi","sequence":"additional","affiliation":[{"name":"Research Center for Modeling in Health Institute of Futures Studies in Health Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouzar","family":"Nakhaee","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.12.110783"},{"key":"e_1_2_6_3_1","volume-title":"World drug report 2010","author":"UNODC","year":"2010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826080701772348"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7517-3-12"},{"key":"e_1_2_6_6_1","first-page":"44","article-title":"The case for considering quality of life in addiction research and clinical practice","volume":"6","author":"Laudet AB","year":"2011","journal-title":"Addict Sci Clin Pract"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2005.02.007"},{"key":"e_1_2_6_8_1","unstructured":"Ministry of Health & Medical Education of Iran.Findings of Piloting of Methadone maintenance Therapy. Office of Substance Abuse Prevention and Treatment(2005). Available at:http:\/\/www.sapto.hbi.ir\/kindex4.htm(accessed February 2013) [Persian]."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina43030029"},{"key":"e_1_2_6_10_1","volume-title":"Evaluation of substance use treatment programmes","author":"United Nations Office on Drugs and Crime UNODC","year":"2009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10826084.2010.517726"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2003.00302.x"},{"key":"e_1_2_6_13_1","volume-title":"Opiate dependence treatment protocol with agonist drugs","author":"Mohsenifar S","year":"2008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta11090"},{"key":"e_1_2_6_15_1","first-page":"60","article-title":"The effectiveness of emotion regulation training and cognitive therapy on the emotional and addictional problems of substance abusers","volume":"2","author":"Azizi A","year":"2010","journal-title":"Iran J Psychiat"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10597-009-9282-8"},{"key":"e_1_2_6_17_1","first-page":"1","article-title":"The 12\u2010item General Health Questionnaire (GHQ\u201012): translation and validation study of the Iranian version","volume":"13","author":"Montazeri A","year":"2003","journal-title":"Health Qual Life Outcomes"},{"key":"e_1_2_6_18_1","volume-title":"Treatment outcomes: what we know and what we need to know","author":"Gossop M","year":"2005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002207.pub3"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2006.11.008"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00952991003736389"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1465-3362.2009.00157.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02249.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.addbeh.2005.05.013","article-title":"Reasons for dropout from drug abuse treatment: symptoms, personality, and motivation","volume":"3","author":"Ball SA","year":"2006","journal-title":"Addict Behav"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2003.00335.x"}],"container-title":["Drug and Alcohol Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdar.12112","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dar.12112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:32:49Z","timestamp":1696321969000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dar.12112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,16]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/dar.12112"],"URL":"https:\/\/doi.org\/10.1111\/dar.12112","archive":["Portico"],"relation":{},"ISSN":["0959-5236","1465-3362"],"issn-type":[{"value":"0959-5236","type":"print"},{"value":"1465-3362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,16]]},"assertion":[{"value":"2013-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}