{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:42:25Z","timestamp":1772012545096,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Northern Terrritory Research and Innovation Board","award":["07-16"],"award-info":[{"award-number":["07-16"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction and Aims<\/jats:title><jats:p>Alcohol rapidly reduces thiamine among alcohol\u2010dependent individuals. Poor diet and alcohol's impact on absorption, storage, activation and excretion of thiamine are thought to be the mechanisms. Previous literature identifies magnesium as an important cofactor in thiamine utilisation, which might also be compromised in alcohol dependent patients. The aim was to describe the thiamine status and clinical profile for a sample of heavy alcohol users entering the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lice <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prings <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital in the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orthern <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>erritory of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia and to examine the relationship between thiamine deficiency, magnesium deficiency and cognitive functioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>Cross\u2010sectional study examining thiamine pyrophosphate (<jats:styled-content style=\"fixed-case\">TPP<\/jats:styled-content>) and magnesium concentrations for a sample of 62 males and 43 females (<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\u2009=\u2009105; <jats:italic>n<\/jats:italic>\u2009=\u200988 <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>boriginal, <jats:italic>n<\/jats:italic>\u2009=\u200913 non\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndigenous). Cognition was assessed using the <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>owland <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversal <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ementia <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TPP<\/jats:styled-content> concentrations were within or above the reference range. Aboriginal patients had significantly lower <jats:styled-content style=\"fixed-case\">TPP<\/jats:styled-content> than non\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndigenous patients. A marginally significant difference was found between individuals with thiamine supplementation recorded within the previous 20 days compared with those without. Mean serum magnesium was in the low normal range with magnesium deficiency (i.e. &lt;0.80\u2009mmol\u2009<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>) present in 48% of those tested. Serum magnesium (but not <jats:styled-content style=\"fixed-case\">TPP<\/jats:styled-content>) concentrations correlated positively with cognitive test scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>Despite increased exposure to risk factors for <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>ernicke <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orsakoff <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>yndrome, no patient had <jats:styled-content style=\"fixed-case\">TPP<\/jats:styled-content> concentrations below the reference range. High patient readmission and aggressive thiamine treatment policies may explain this finding. However, low magnesium may be prevalent and could contribute to impaired thiamine utilisation. <jats:italic>[Dingwall KM, Delima JF, Gent D, Batey RG. Hypomagnesaemia and its potential impact on thiamine utilisation in patients with alcohol misuse at the Alice Springs Hospital.<\/jats:italic> Drug Alcohol Rev <jats:italic>2015]<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.12237","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T09:47:45Z","timestamp":1424339265000},"page":"323-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hypomagnesaemia and its potential impact on thiamine utilisation in patients with alcohol misuse at the <scp>A<\/scp>lice <scp>S<\/scp>prings <scp>H<\/scp>ospital"],"prefix":"10.1111","volume":"34","author":[{"given":"Kylie Maree","family":"Dingwall","sequence":"first","affiliation":[{"name":"Menzies School of Health Research Institute of Advanced Studies Charles Darwin University  Alice Springs Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Flavia","family":"Delima","sequence":"additional","affiliation":[{"name":"Alice Springs Hospital Northern Territory Government Department of Health  Alice Springs Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Gent","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Institute of Advanced Studies Charles Darwin University  Alice Springs Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Gordon","family":"Batey","sequence":"additional","affiliation":[{"name":"Alice Springs Hospital Northern Territory Government Department of Health  Alice Springs Australia"},{"name":"Department of Medicine Flinders University  Alice Springs Australia"},{"name":"Central Clinical School Sydney University  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"134","article-title":"The role of thiamine deficiency in alcoholic brain disease","volume":"27","author":"Martin PR","year":"2003","journal-title":"Alcohol Res Health"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1983.tb05403.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.189"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2011.tb02966.x"},{"key":"e_1_2_6_6_1","unstructured":"World Health Organisation.Thiamine deficiency and its prevention and control in major emergencies.1999."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70104-7"},{"key":"e_1_2_6_8_1","unstructured":"Australian Bureau of Statistics.Apparent consumption of alcohol Australia 2007\u20132008 [Cat. No. 4307.0.55.001].Canberra:Australian Government Publishing Service 2009."},{"key":"e_1_2_6_9_1","unstructured":"2010 R Chondur Z Wang Alcohol use in the Northern Territory"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2010.tb03905.x"},{"key":"e_1_2_6_11_1","unstructured":"Australian Bureau of Statistics.Experimental estimates of Aboriginal and Torres Strait Islander Australians [Cat.No.3238.0.55.001].Canberra:Australian Government Publishing Service 2006."},{"key":"e_1_2_6_12_1","unstructured":"Australian Institute of Health and Welfare.End\u2010stage kidney disease in Australia: Total incidence 2003\u20132007 [Cat. no. PHE143].Canberra:Australian Institute of Health and Welfare 2011."},{"key":"e_1_2_6_13_1","unstructured":"Australian Institute of Health and Welfare.Aboriginal and Torres Strait Islander health performance framework 2008 report: detailed analyses. Cat. no. IHW 22.Canberra:AIHW 2008."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.1997.tb01670.x"},{"key":"e_1_2_6_15_1","unstructured":"National Health and Medical Research Council.Nutrition in Aboriginal and Torres Strait Islander peoples: an information paper.Canberra:Commonwealth of Australia 2000."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja12.11407"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104831"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0946-672X(11)80026-X"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb13005.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.37.8.959"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1985.tb08836.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00182-8"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0036933013496944"},{"key":"e_1_2_6_24_1","volume-title":"The alcohol use disorders identification test: guidelines for use in primary care","author":"Babor TF","year":"2001"},{"key":"e_1_2_6_25_1","unstructured":"Nutrition Screening Initiative.Report of nutrition screening I: toward a common view.Washington DC:Nutrition Screening Initiative 1991."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610204000043"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.069005"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-13-42"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/00048670903393670"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-3270-7_6"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.099077"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004033.pub2"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/37.6.513"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2012.04.008"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03153.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.1.51"}],"container-title":["Drug and Alcohol Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdar.12237","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dar.12237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T17:06:56Z","timestamp":1694452016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dar.12237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,19]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/dar.12237"],"URL":"https:\/\/doi.org\/10.1111\/dar.12237","archive":["Portico"],"relation":{},"ISSN":["0959-5236","1465-3362"],"issn-type":[{"value":"0959-5236","type":"print"},{"value":"1465-3362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,19]]},"assertion":[{"value":"2014-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}