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It has received growing attention as a therapy for managing addictions because of its capacity to restore homeostasis to brain glutamate systems disrupted in addiction and thereby reduce craving and the risk of relapse. N\u2010acetylcysteine also has antioxidant properties that protect against methamphetamine\u2010induced toxicity and it may therefore assist in the management of the neuropsychiatric and neurocognitive effects of methamphetamine. This commentary overviews the actions of N\u2010acetylcysteine and evidence for its efficacy in treating addiction with a particular focus on its potential utility for methamphetamine dependence. We conclude that the preliminary evidence indicates a need for full\u2010scale trials to definitively establish whether N\u2010acetylcysteine has a therapeutic benefit and the nature of this benefit, for managing methamphetamine dependence.<\/jats:italic> [McKetin R, Dean O, Baker A. L, Carter G, Turner A, Kelly P. J, Berk M. 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