{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T21:53:15Z","timestamp":1778536395238,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T00:00:00Z","timestamp":1478563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction and Aims<\/jats:title><jats:p>Opioid dependence remains the main type of illicit substance used in Malaysia, which has an estimated 187 771 opiate users. There are currently 333 active methadone maintenance treatment centres nationwide. Although methadone has proven to be an effective maintenance therapy, it has clinical concerns which can have an impact on its effectiveness and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Methods and Results<\/jats:title><jats:p>A case series of seven patients from Malaysian private and public hospital settings who had an adverse reaction with methadone is discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>Despite methadone being an effective therapy for opioid dependence, there is a need for other alternative effective therapies, such as naltrexone, buprenorphine and the co\u2010formulation of buprenorphine\u2010naloxone, to be made available to physicians in both public and private sectors. There is need for individual treatment consideration to avoid adverse effects, drug\u2013drug interactions, overdosing and in the presence of co\u2010morbidities. An emphasis on safe storage of takeaway methadone is also needed. 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Methadone complications amongst opioid\u2010dependent patients in Malaysia: A case series. <jats:italic>Drug Alcohol Rev<\/jats:italic> 2018;37:147\u2013151]<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.12456","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T07:54:35Z","timestamp":1478591675000},"page":"147-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Methadone complications amongst opioid\u2010dependent patients in Malaysia: A case series"],"prefix":"10.1111","volume":"37","author":[{"given":"Philip","family":"George","sequence":"first","affiliation":[{"name":"School of Medicine International Medical University  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balasingam","family":"Vicknasingam","sequence":"additional","affiliation":[{"name":"Centre for Drug Research Universiti Sains  George Town Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivakumar","family":"Thurairajasingam","sequence":"additional","affiliation":[{"name":"School of Medicine Monash University  Subang Jaya Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parameswaran","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Hospital Kuala Pilah  Kuala Pilah Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haslina","family":"Mohd Yusof","sequence":"additional","affiliation":[{"name":"Hospital Permai  Johor Bahru Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Azhar Bin Mohd","family":"Yasin","sequence":"additional","affiliation":[{"name":"School of Medicine Monash University  Subang Jaya Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zia U. Bahkt Sultan","family":"Shah","sequence":"additional","affiliation":[{"name":"School of Medicine International Medical University  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2013.09.033"},{"key":"e_1_2_6_3_1","unstructured":"Pharmaceutical service division Ministry of Health Malaysia.Pharmacy programme annual report2014. Available at:http:\/\/www.pharmacy.gov.my\/v2\/sites\/default\/files\/document\u2010upload\/laporan\u2010tahunan\u2010annual\u2010report\u20102014_0.pdf(accessed March 2016)."},{"key":"e_1_2_6_4_1","unstructured":"UNAIDS.Global AIDS response progress report.2014. 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