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During this period, the brain is wired to underestimate risk and overestimate pleasure, which primes young people towards risky, pleasure\u2010oriented experiences. Substance use during this time can hinder brain maturation and lead to development related disorders. However, young people are the most likely to drink at risky quantities, use cannabis, MDMA and cocaine in the previous 12\u2009months than any other age group. Despite this, there are no validated, age\u2010appropriate prevention programs targeting school leavers, which leaves a group of young people to navigate a landscape where drug use is the most common, without formal support. Drug and alcohol prevention programs should be developed for this age group that combine features of universal prevention programs and targeted intervention programs to support the wider range of drug use behaviours relevant to this older audience. This article outlines potential evidence\u2010based strategies that programs could focus on in the future.<\/jats:p>","DOI":"10.1111\/dar.12914","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T20:36:46Z","timestamp":1552423006000},"page":"327-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Alcohol and other drug prevention for older adolescents: It's a no brainer"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9596-9484","authenticated-orcid":false,"given":"Jennifer","family":"Debenham","sequence":"first","affiliation":[{"name":"The Matilda Centre The University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Newton","sequence":"additional","affiliation":[{"name":"The Matilda Centre The University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1335-1382","authenticated-orcid":false,"given":"Louise","family":"Birrell","sequence":"additional","affiliation":[{"name":"The Matilda Centre The University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Askovic","sequence":"additional","affiliation":[{"name":"The University of Sydney Business School The University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/13158"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11121-012-0345-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2009.05.016"},{"key":"e_1_2_5_5_1","first-page":"3","article-title":"Illegal drug\u2010attributable mortality and potential years of life lost in Canada 2002: conclusions for prevention and policy","volume":"27","author":"Popova S","year":"2005","journal-title":"Contemp Drug Probl"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2005.01338.x"},{"key":"e_1_2_5_7_1","volume-title":"National Drug Strategy Household Survey 2016: detailed findings. 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