{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:57:04Z","timestamp":1747184224830,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007543","name":"Grantov\u00e1 Agentura, Univerzita Karlova","doi-asserted-by":"publisher","award":["202120","952218"],"award-info":[{"award-number":["202120","952218"]}],"id":[{"id":"10.13039\/100007543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["Q06\/LF1"],"award-info":[{"award-number":["Q06\/LF1"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Drug\u2010related mortality is a key epidemiological indicator that is collected nationally and internationally. Significant efforts were made in 2006\u20132007 to improve the quality of data concerning drug\u2010related mortality in the Czech Republic. The aim of this article is to identify the effect of a quality improvement project on the drug\u2010induced mortality data reported in the General Mortality Registry (GMR), and to demonstrate how to identify, quantify and interpret changes in drug\u2010induced mortality based on the example of the Czech Republic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We extracted data on illicit drug\u2010induced deaths from the Czech Republic GMR and Special Mortality registry (SMR) for the years between 2004 and 2012, and aggregated monthly and quarterly time series. We applied a new procedure to identify structural breakpoints in time series based on dating structural changes in standard linear regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the GMR, breakpoints were identified in three time series: (i) opioid\u2010related deaths; (ii) other stimulant\u2010related deaths; and (iii) total drug\u2010induced deaths. In the SMR, the structural breaks were identified for opioids, volatile substances and selection D time series. In each of these time series, the analysis identified a decrease in the intercepts in the different segments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>The structural breaks identified and quantified in the GMR time series were plausibly caused by the quality improvement efforts that started in 2006. These results demonstrate that it is critical for the analysis and use of drug mortality data collected in the registries to identify practice changes in the relevant registries, to quantify their influence and to adjust mortality estimates accordingly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.13296","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T21:06:54Z","timestamp":1619039214000},"page":"1207-1218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The identification of artefacts in reporting of drug\u2010induced deaths using structural breaks analysis of time series statistics"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0318-3589","authenticated-orcid":false,"given":"Benjamin","family":"Petru\u017eelka","sequence":"first","affiliation":[{"name":"Department of Addictology, First Faculty of Medicine Charles University and General University Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-5744","authenticated-orcid":false,"given":"Viktor","family":"Mrav\u010d\u00edk","sequence":"additional","affiliation":[{"name":"Department of Addictology, First Faculty of Medicine Charles University and General University Hospital  Prague Czech Republic"},{"name":"National Monitoring Centre for Drugs and Addiction, Office of the Government of the Czech Republic  Prague Czech Republic"},{"name":"National Institute of Mental Health  Klecany Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7265-6514","authenticated-orcid":false,"given":"Miroslav","family":"Bart\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Addictology, First Faculty of Medicine Charles University and General University Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2580-0835","authenticated-orcid":false,"given":"Thomas F.","family":"Babor","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Connecticut School of Medicine  Farmington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"volume-title":"Drug\u2010related deaths and mortality in Europe: update from the EMCDDA expert network","year":"2019","author":"European Monitoring Centre for Drugs and Drug Addiction","key":"e_1_2_8_2_1"},{"unstructured":"Commission on Narcotic Drugs.Drug information systems: principles structures and indicators (Lisbon Consensus) (Commission on Narcotic Drugs Forty\u2010Third Session Item 4(a) and (b) of the Provisional Agenda E\/CN.7\/2000\/CRP.3). 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