{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:49Z","timestamp":1787014069797,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cardiovascular disease is a health concern in ageing population with opioid use disorders (OUD). The study aims to analyse the cardiovascular risk factors in individuals with OUD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An observational study was carried out to compare cardiovascular risk factors of adults &gt;50\u2009years with OUD on methadone therapy from public outpatient drug treatment centres, with that of an age\u2010 and gender\u2010matched sample (ratio of 1:5) of subjects from a sample of the Spanish population (REGICOR cohort). High cardiovascular risk (HCVR) at 10\u2009years was defined according to Framingham\u2010REGICOR and SCORE risk functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The individuals studied included 94 people with OUD and 495 from the general population; the mean age was 55.7\u2009\u00b1\u20094.8\u2009years and 432 (72.7%) were men. Obesity (21.2% vs. 35.2%), hypertension (26.3% vs. 42.1%), total cholesterol (30.3% vs. 65.4%) and LDL\u2010cholesterol\u2009\u2265130\u2009mg\/dL (27.2% vs. 59.3%) were significantly more prevalent in the general population group, while tobacco smoking (96.0% vs. 25.9%), low HDL\u2010cholesterol (46.5% vs. 21.2%), hypertriglyceridaemia (39.4% vs. 18.8%) and atherogenic dyslipidaemia (30.3% vs. 10.5%) were significantly higher in individuals with OUD. Differences in abdominal obesity (62.6% vs. 65.3%) were not significant. HCVR was more prevalent in patients with OUD: 15.2% versus 5.8% (Framingham\u2010REGICOR function) and 21.2% versus 11.3% (SCORE function).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusions<\/jats:title>\n                    <jats:p>Older adults with OUD on methadone therapy have a different prevalence of cardiovascular risk factors and HCVR than the general population. Preventive measures, particularly tobacco smoking cessation and weight control, should be included in the routine care of individuals with OUD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dar.13449","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T23:58:38Z","timestamp":1645142318000},"page":"1078-1084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["High cardiovascular risk in older patients with opioid use disorder: Differences with the general population"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8407-3538","authenticated-orcid":false,"given":"Gabriel","family":"Vallecillo","sequence":"first","affiliation":[{"name":"Drug Addiction Program Instituto de Neuropsiquiatr\u00eda y Adicciones  Barcelona Spain"},{"name":"IMIM\u2010Hospital del Mar Medical Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Pedro\u2010Botet","sequence":"additional","affiliation":[{"name":"Lipid and Cardiovascular Risk Unit, Department of Endocrinology Hospital del Mar  Barcelona Spain"},{"name":"Departmento de Medicina Universidad Autonoma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Registre Giron\u00ed del COR (REGICOR) Group IMIM\u2010Hospital del Mar Medical Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Registre Giron\u00ed del COR (REGICOR) Group IMIM\u2010Hospital del Mar Medical Research Institute  Barcelona Spain"},{"name":"Cardiovascular Epidemiology and Genetics Group IMIM\u2010Hospital del Mar Medical Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Elosua","sequence":"additional","affiliation":[{"name":"Cardiovascular Epidemiology and Genetics Group IMIM\u2010Hospital del Mar Medical Research Institute  Barcelona Spain"},{"name":"CIBERCV of Cardiovascular Research  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Camps","sequence":"additional","affiliation":[{"name":"Registre Giron\u00ed del COR (REGICOR) Group IMIM\u2010Hospital del Mar Medical Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Torrens","sequence":"additional","affiliation":[{"name":"Drug Addiction Program Instituto de Neuropsiquiatr\u00eda y Adicciones  Barcelona Spain"},{"name":"IMIM\u2010Hospital del Mar Medical Research Institute  Barcelona Spain"},{"name":"Departmento de Medicina Universidad Autonoma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Marrugat","sequence":"additional","affiliation":[{"name":"Registre Giron\u00ed del COR (REGICOR) Group IMIM\u2010Hospital del Mar Medical Research Institute  Barcelona Spain"},{"name":"CIBERCV of Cardiovascular Research  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"United Nations Office on Drugs and Crime (UNODC).World Drug Report 2018 [Internet].2018Available at:https:\/\/www.unodc.org\/wdr2018\/. 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