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This is the first Greek study to evaluate the concept of the minority stress theory on sexual minorities' substance use and unprotected sexual intercourse. In addition, this is among the first international studies to examine whether periods of adverse economic conditions are associated with sexual minorities' substance use and unprotected sexual intercourse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two\u2010panel datasets covering the periods 2013\u20132014 and 2018\u20132019 were used to determine the perceived social rejection, that is, whether sexual minorities have been rejected by friends, treated unfairly in educational and\/or workplace environments, treated negatively in social situations and received poor health and public services due to their sexuality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The estimates indicate that perceived social rejection is associated with the increased consumption of tobacco (by 9.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), alcohol (by 7.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and cannabis (by 12.5%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), as well as unprotected sexual intercourse (by 6.5%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). In the first three cases, the magnitude of the associations is stronger for men than women and there is increased cannabis consumption during periods of deteriorated economic conditions (by 5.5%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>In the European Union, reducing stigma, substance use, risky sexual behaviours and health inequalities for sexual minorities is a goal of public health. If minority stress is correlated with substance use and risky sexual behaviours leading to detrimental physical\/mental health outcomes then prevention and support interventions should be designed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.13500","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T17:01:11Z","timestamp":1656003671000},"page":"1341-1354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The perceived social rejection of sexual minorities: Substance use and unprotected sexual intercourse"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-6678","authenticated-orcid":false,"given":"Nick","family":"Drydakis","sequence":"first","affiliation":[{"name":"School of Economics, Finance and Law, Centre for Pluralist Economics, Faculty of Business and Law Anglia Ruskin University  Cambridge UK"},{"name":"Pembroke College, University of Cambridge  Cambridge UK"},{"name":"Centre for Science and Policy, University of Cambridge  Cambridge UK"},{"name":"Global Labor Organization  Essen Germany"},{"name":"Institute of Labor Economics  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.93.2.262"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/lgbt.2016.0117"},{"key":"e_1_2_11_4_1","first-page":"e1184","article-title":"Health care disparities among lesbian, gay, bisexual, and transgender youth: a literature review","volume":"9","author":"Hafeez H","year":"2017","journal-title":"Cureus"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-57365-6_36-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.05.008"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11121-013-0393-7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000180"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2012.73.783"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/17460913.3.5.507"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2807\/ese.16.36.19962-en"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","unstructured":"DrydakisN.Sexual orientation discrimination in the labor market against gay men. 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