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The current study aimed to assess whether the initial implementation of Canada's cannabis legalisation (via the <jats:italic>Cannabis Act<\/jats:italic>) on 17 October 2018 might be associated with youth harm, as assessed by emergency department visits for cannabis\u2010related disorders\/poisoning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used Ontario and Alberta, Canada emergency department data from 1 April 2015 to 31 December 2019. We identified all cannabis\u2010related disorders\/poisoning (ICD\u201010 CA: F12.X, T40.7) emergency department visits of youth (<jats:italic>n<\/jats:italic>\u00a0=\u200913,615), defined as patients younger than the minimum legal cannabis sales age (18\u2009years, Alberta; 19\u2009years, Ontario). Seasonal Autoregressive Integrated Moving Average (SARIMA) models were employed to assess the impact of legalisation on weekly counts of cannabis\u2010related harms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final SARIMA intervention (step) parameter indicated a post\u2010legalisation increase of 14.7 (95% confidence interval [CI] 5.0; 24.3, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) weekly youth cannabis\u2010related disorder\/poisoning presentations to Ontario\/Alberta emergency department settings, equivalent to an increase of 20.0% (95% CI 6.2%; 33.9%). There was no evidence of associations between cannabis legalisation and comparison series of youth alcohol, opioid or appendicitis emergency department episodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion\/Conclusion<\/jats:title><jats:p>Our findings require replication and extension but are consistent with the possibility that the implementation of the <jats:italic>Cannabis Act<\/jats:italic> was associated with an increase in youth cannabis\u2010related presentations to Ontario\/Alberta emergency departments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.13637","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T07:25:49Z","timestamp":1678692349000},"page":"1104-1113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of Canada's cannabis legalisation on youth emergency department visits for cannabis\u2010related disorders and poisoning in Ontario and Alberta, 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