{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:22:42Z","timestamp":1789788162370,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia characterised by the loss of REM sleep muscle atonia and the enactment of dreams. Acute RBD associated with alcohol withdrawal syndrome is known, but the studies are limited, particularly on its neurobiological underpinnings and management alongside the withdrawal state. This work attempts to address this using a case study and relevant literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 40\u2010year\u2010old male with alcohol dependence (for 20\u2009years) reported new\u2010onset terrifying nightmares and violent behaviours in his sleep precipitated by alcohol withdrawal states for the last 18\u2009months. The polysomnographic finding of REM\u2010without\u2010atonia supported the diagnosis of RBD. He was treated with chlordiazepoxide 100\u2009mg\/day (gradually tapered and stopped) and thiamine supplements. Post\u2010discharge, he remained abstinent and symptom\u2010free during the three\u2009months of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>RBD related to alcohol withdrawal syndrome has been previously described in a few anecdotal reports. Sudden withdrawal from central nervous system suppressants like alcohol is hypothesised to cause a homeostatic imbalance in gamma\u2010aminobutyric acid (GABA) pathways and \u2018REM rebound\u2019, resulting in the clinical and polysomnographic picture of RBD. Benzodiazepines have been found to be useful in both RBD and alcohol withdrawal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alcohol withdrawal syndrome may present with acute RBD, which can be treated with a short course of benzodiazepine. However, further studies are needed to explore the long\u2010term course of RBD in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.13809","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T06:58:30Z","timestamp":1706597910000},"page":"760-763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute <scp>REM<\/scp> sleep behaviour disorder associated with alcohol withdrawal: A case report and literature review"],"prefix":"10.1111","volume":"43","author":[{"given":"Radhika","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Department of Psychiatry All India Institute of Medical Sciences  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6559-280X","authenticated-orcid":false,"given":"Tathagata","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry All India Institute of Medical Sciences  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0537-9454","authenticated-orcid":false,"given":"Biswa Ranjan","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Psychiatry All India Institute of Medical Sciences  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0487-0404","authenticated-orcid":false,"given":"Arpit","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry All India Institute of Medical Sciences  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.145.5.652a"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(02)00014-X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00414-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.2.331"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.1993.tb00093.x"},{"key":"e_1_2_11_7_1","first-page":"153","volume-title":"Rapid\u2010eye\u2010movement sleep behavior disorder","author":"Provini F","year":"2018"},{"key":"e_1_2_11_8_1","volume-title":"International classification of sleep disorders","author":"American Academy of Sleep Medicine","year":"2023"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.10424"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69010126.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agn079"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.1.69"}],"container-title":["Drug and Alcohol Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dar.13809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T09:42:55Z","timestamp":1709286175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dar.13809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/dar.13809"],"URL":"https:\/\/doi.org\/10.1111\/dar.13809","archive":["Portico"],"relation":{},"ISSN":["0959-5236","1465-3362"],"issn-type":[{"value":"0959-5236","type":"print"},{"value":"1465-3362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]},"assertion":[{"value":"2023-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}