{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:11:26Z","timestamp":1770750686661,"version":"3.50.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["IN\u2010987\u20105282"],"award-info":[{"award-number":["IN\u2010987\u20105282"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hepatitis C virus (HCV) prevalence is high in the mental health population. We sought to evaluate testing and treatment uptake for HCV following the implementation of a universal nurse led study in inpatient and outpatient mental health populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2018 to December 2020, we screened mental health inpatients (<jats:italic>n<\/jats:italic>\u2009=\u2009322) and community mental health patients (<jats:italic>n<\/jats:italic>\u2009=\u2009615) for HCV with either specialist hepatology nurses or mental health nurses (mental health nurse).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>75.5% (464\/615) of community patients and 100% (322\/322) of inpatients consented to screening, with an HCV antibody\u2010positive prevalence of 12.7% (59\/464) in community patients and 19.6% (63\/322) in inpatients. RNA detectable prevalence was 4.0% (22\/464) and 7.5% (24\/322), respectively. Community patients who were screened by specialist hepatology nurses were more likely to consent to screening (94.4% vs. 45.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but had lower proportion of HCV antibody (10.5% vs. 20.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and RNA detectable (4.0% vs. 7.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.018) when compared to mental health nurse screening. Engagement with treatment was 27.0% of community mental health patients and 45.8% of mental health inpatients undergoing treatment. All patients undergoing treatment and underwent sustained viral response (SVR) testing achieved SVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>Universal screening of HCV using a nurse\u2010led model has high rates of success in mental health patients with high proportions undergoing screening, with no reduction in the rates of SVR achieved with DAA therapy compared to the general population. Further work is needed to bridge the gap between identification of HCV and treatment among mental health patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.13854","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T06:45:01Z","timestamp":1716360301000},"page":"1247-1255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Micro\u2010elimination of chronic hepatitis C virus in mental health settings: A prospective multicentre pragmatic trial"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0913-7180","authenticated-orcid":false,"given":"Cameron","family":"Gofton","sequence":"first","affiliation":[{"name":"Storr Liver Centre, Westmead Institute for Medical Research Westmead Hospital and The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Gastroenterology and Hepatology Royal North Shore Hospital  Sydney New South Wales Australia"},{"name":"Department of Gastroenterology and Hepatology Bankstown\u2010Lidcombe Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kindness","family":"Bondezi","sequence":"additional","affiliation":[{"name":"Storr Liver Centre, Westmead Institute for Medical Research Westmead Hospital and The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Kotze","sequence":"additional","affiliation":[{"name":"Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"McKee","sequence":"additional","affiliation":[{"name":"Storr Liver Centre, Westmead Institute for Medical Research Westmead Hospital and The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Yesudoss","sequence":"additional","affiliation":[{"name":"Western Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"McCaughan","sequence":"additional","affiliation":[{"name":"AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney Local Health District, Centenary Institute The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[{"name":"Storr Liver Centre, Westmead Institute for Medical Research Westmead Hospital and The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07378-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15131"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0272518"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13680"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00472-6"},{"key":"e_1_2_10_7_1","unstructured":"WHO.Global health sector strategy on viral hepatitis 2016\u20102021: towards ending viral hepatitis. 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