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This study investigates whether the rising THC concentration in Germany is associated with an increase in cannabis\u2010related diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The number of insured persons with at least one cannabis\u2010related ICD\u201010 F12 diagnosis (e.g., harmful use, dependence) in outpatient care was provided by statutory health insurance funds between 2009 and 2021. The dependent variable is the ratio of (a) the number of insured persons with at least one F12 diagnosis to (b) all insured persons who have used cannabis in the last year. Information on THC concentration in cannabis flower was provided by law enforcement agencies. Using generalised mixed linear models, the dependent variable was predicted by the median THC concentration in cannabis flower.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The regression results show that an increase in THC concentration by one percentage point is significantly associated with an increase in the proportion of diagnoses (women: +0.17; men: +0.42). THC concentration positively predicted the proportion of diagnoses in all 16 federal states for men and in 15 federal states for women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>Compared to low\u2010potency products, using high\u2010potency products may pose additional health risks, which may be particularly pronounced in men. Acknowledging the limitations of the ecological study design and uncertainties inherent to the analysed data, further investigations on the sex\u2010specific impact of THC exposure are required. Limiting the THC concentration in cannabis products and closely monitoring THC consumption in the population appears necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.13923","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:50:28Z","timestamp":1724295028000},"page":"1764-1772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Can the <scp>THC<\/scp> concentration predict the number of patients with cannabis\u2010related diagnoses?"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-3760","authenticated-orcid":false,"given":"Jakob","family":"Manthey","sequence":"first","affiliation":[{"name":"Centre of Interdisciplinary Addiction Research, Department of Psychiatry and Psychotherapy University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Department of Psychiatry, Medical Faculty University of Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0851-6330","authenticated-orcid":false,"given":"Moritz","family":"Rosenkranz","sequence":"additional","affiliation":[{"name":"Centre of Interdisciplinary Addiction Research, Department of Psychiatry and Psychotherapy University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Jonas","sequence":"additional","affiliation":[{"name":"Zentralinstitut f\u00fcr die kassen\u00e4rztliche Versorgung  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-7700","authenticated-orcid":false,"given":"Larissa","family":"Schwarzkopf","sequence":"additional","affiliation":[{"name":"IFT Institut f\u00fcr Therapieforschung, Mental Health and Addiction Research  Munich Germany"},{"name":"Institute for Medical Information Processing, Biometry and Epidemiology, LMU Munich Marchioninistrasse 17  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Miriam Schneider","author":"Eva Hoch CMF","year":"2019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2020.106479"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.06.014"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2022.109582"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(22)00161-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.1035"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715001178"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2023.107740"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717003877"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.16356"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckab207"},{"key":"e_1_2_10_13_1","volume-title":"Bericht 2022 des nationalen REITOX\u2010Knotenpunkts an die EMCDDA (Datenjahr 2021\/2022)","author":"Schneider F","year":"2022"},{"key":"e_1_2_10_14_1","volume-title":"Bericht 2013 des nationalen REITOX\u2010Knotenpunkts an die EBDD","author":"Pfeiffer\u2010Gerschel T","year":"2013"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40429-021-00357-9"},{"key":"e_1_2_10_16_1","volume-title":"Diagnosedaten der Krankenh\u00e4user ab 2000 (Eckdaten der vollstation\u00e4ren Patienten und Patientinnen). 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