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We used syndemic theory to assess how psychosocial factors sustain methamphetamine use and hinder recovery efforts for SMM living with HIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A triangulation of network analyses and constructivist grounded theory approaches is utilised to elucidate pathways through which psychosocial factors influence methamphetamine use among this population. Survey data (<jats:italic>N<\/jats:italic>\u2009=\u2009129) are used for quantitative analyses and a purposive sub\u2010sample (<jats:italic>n<\/jats:italic>\u2009=\u200924) was recruited for semi\u2010structured interviews for qualitative analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>The network analysis revealed two statistically significant bivariate associations: between post\u2010traumatic stress disorder and depression symptoms (<jats:italic>b<\/jats:italic>\u2009=\u20090.37, SD\u2009=\u20090.07, 95% confidence interval [0.23, 0.49]) and between depression symptoms and negative affect (<jats:italic>b<\/jats:italic>\u2009=\u20090.26, SD\u2009=\u20090.07, 95% confidence interval [0.12, 0.38]). Findings from the constructivist grounded theory analysis supplement the network analysis by offering a nuanced take on how negative affect, post\u2010traumatic stress disorder, and depression symptoms operate synergistically to promote methamphetamine use and impede recovery efforts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>Participants relay experiences of using methamphetamine to cope with these psychosocial factors through avoidance, escapism, mood elevation, and numbing of emotions. Findings suggest that centring these psychosocial factors may inform more effective, holistic interventions for this high\u2010priority population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.13941","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T10:02:28Z","timestamp":1727776948000},"page":"1913-1928","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mapping a psychosocial syndemic among methamphetamine\u2010using sexual minority men living with HIV"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0217-7892","authenticated-orcid":false,"given":"Walter","family":"G\u00f3mez","sequence":"first","affiliation":[{"name":"Jane Addams College of Social Work University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper 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