{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:34:13Z","timestamp":1789842853012,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Nitrous oxide is widely used for recreational purposes, leading to constantly increasing cases of severe use disorder. Although the scope of the deleterious consequences of nitrous oxide use is relatively well described for neurological and thromboembolic\u2010related complications, this is not the case in the psychiatric field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>We report the case of a 20\u2010year\u2010old woman who developed nitrous oxide\u2010induced peripheral neuropathy. The patient had a history of frequent nitrous oxide use. One year later, she presented with catatonia linked to nitrous oxide use, associated with vitamin B12 deficiency and hyperhomocysteinemia, with no apparent psychiatric causes. Nine months after the catatonic episode, she experienced a psychotic episode linked to long\u2010term nitrous oxide use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>To the best of our knowledge, this is the first report describing a cascade of neurologic and psychiatric complications of chronic use of nitrous oxide. Hyperhomocysteinemia caused by nitrous oxide consumption could explain the occurrence of such events. Homocysteine, methylmalonic acid, and active vitamin B12 are key biomarkers to determine the involvement of nitrous oxide in psychiatric symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.14012","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T04:58:41Z","timestamp":1738645121000},"page":"908-912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["First episode of catatonia followed by a psychotic episode related to chronic nitrous oxide use: A case report"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0173-6437","authenticated-orcid":false,"given":"Tanguy","family":"Taillefer de Laportali\u00e8re","sequence":"first","affiliation":[{"name":"Department of Pharmacy Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilien","family":"Redon","sequence":"additional","affiliation":[{"name":"Department of Emergency, Crisis and Liaison Psychiatry Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Roussin","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Pharmacology, Addictovigilance Centre Toulouse University Hospital, University of Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Willemet","sequence":"additional","affiliation":[{"name":"Department of Emergency, Crisis and Liaison Psychiatry Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Very","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy, and Art Therapy Toulouse University Hospital  Toulouse France"},{"name":"ToNIC, Toulouse NeuroImaging Center Universit\u00e9 de Toulouse, Inserm, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Olivier","sequence":"additional","affiliation":[{"name":"Department of Emergency, Crisis and Liaison Psychiatry Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Lapeyre\u2010Mestre","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Pharmacology, Addictovigilance Centre Toulouse University Hospital, University of Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314747"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1167746"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116632375"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2020.01.002"},{"key":"e_1_2_8_6_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction.European drug report 2024: trends and developments.2024[cited 2025 Jan 30]. 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