{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:26:06Z","timestamp":1788297966756,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100021069","name":"Indivior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003921","name":"Department of Health and Aged Care, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>How people connect with opioid agonist treatment is an ongoing concern. Extended\u2010release buprenorphine depot (BUP\u2010XR) has been designed with \u2018retention\u2019 in mind. It is important to consider what makes a difference to clients in helping them to stay connected to treatment over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report findings from the third wave of in\u2010depth interviews with participants (<jats:italic>n<\/jats:italic>\u2009=\u200926) in the Community Long\u2010Acting Buprenorphine (CoLAB) study, tracing accounts of connection, disconnection and reconnection with BUP\u2010XR since initiation into treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Changing situations in treatment delivery and in people's lives created conditions of possibility for connection and disconnection to treatment. Clients used BUP\u2010XR in different ways. Personalisation of dosing regimens and stretching out of time between doses was common, creating a sense of stability for some. For others, this flexibility potentiated fragility in treatment connection. Disconnection from BUP\u2010XR was common, but frequently this was not the ultimate outcome. Treatment connections were shaped by fluctuating life circumstances, with re\u2010connections imagined, attempted and sometimes realised.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and conclusions<\/jats:title><jats:p>Clients' accounts reveal the complexities of how \u2018long\u2010acting\u2019 treatments are made to work over time. Connecting with treatment in the long\u2010term is a process, contingent on social relations, fluctuating life conditions and systems of care. Rather than treating connection and disconnection as opposites, we suggest seeing these as entangled and fluid elements of an ongoing process. What is needed is an adaptive and emergent conceptualisation of what \u2018retention\u2019 in treatment can mean, reflective of how people connect with their treatment and make it work, in practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.14021","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T08:09:29Z","timestamp":1739779769000},"page":"829-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Making long\u2010acting treatment work: Tracing connections with extended\u2010release buprenorphine depot through time"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-9433","authenticated-orcid":false,"given":"Sandra","family":"Gendera","sequence":"first","affiliation":[{"name":"Social Policy Research Centre, UNSW Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2411-7970","authenticated-orcid":false,"given":"Kari","family":"Lancaster","sequence":"additional","affiliation":[{"name":"Centre for Social Research in Health, UNSW Sydney  Sydney Australia"},{"name":"University of Bath  Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-9838","authenticated-orcid":false,"given":"Tim","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Centre for Social Research in Health, UNSW Sydney  Sydney Australia"},{"name":"London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-0386","authenticated-orcid":false,"given":"Carla","family":"Treloar","sequence":"additional","affiliation":[{"name":"Centre for Social Research in Health, UNSW Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-020-06257-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12954-022-00592-x"},{"key":"e_1_2_10_4_1","unstructured":"CapponAM.Opioid agonist therapy. 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