{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:30:42Z","timestamp":1787070642643,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Novel benzodiazepines (NBZN) have increased in availability and use since the mid\u20102000s, with a corresponding rise in associated harms including deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study used data from the Victorian Overdose Deaths Register to explore which specific NBZNs and combinations of NBZNs contributed over time to Victorian overdose deaths between January 2009 and December 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 140 NBZN\u2010involved overdose deaths in Victoria, with an observable increase in deaths from 2019 onward. Eight main groupings of deaths in time were identified, based on contributing NBZNs. Key groupings included etizolam\u2010related deaths between 2019 and 2021, followed by flualprazolam and clonazolam deaths, and later, bromazolam and clobromazolam combinations in 2022\u20132023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>These findings reflect the transiency of NBZNs in Victoria's unregulated drug market and highlight the importance of certain harm reduction measures in addressing increasing NBZN use. These include public education around the risks of using benzodiazepines not dispensed from pharmacies and the use of drug checking services to assist people obtaining benzodiazepines from unregulated drug markets.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.14054","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T06:24:22Z","timestamp":1745303062000},"page":"1285-1289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes over time in novel benzodiazepines contributing to fatal overdoses in Victoria, Australia"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8870-6272","authenticated-orcid":false,"given":"Jennifer L.","family":"Schumann","sequence":"first","affiliation":[{"name":"Victorian Institute of Forensic Medicine  Melbourne Australia"},{"name":"Department of Forensic Medicine Monash University  Melbourne Australia"},{"name":"Monash Addiction Research Centre  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8109-164X","authenticated-orcid":false,"given":"Rebekka","family":"Syrjanen","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Dwyer","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Monash University  Melbourne Australia"},{"name":"Coroners Court of Victoria  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/neurolint14030053"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2021.103512"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.109244"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2019.110101"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkaa098"},{"key":"e_1_2_10_7_1","unstructured":"National Records of Scotland.Drug\u2010related deaths in Scotland in 2018.2019."},{"key":"e_1_2_10_8_1","unstructured":"National Records of Scotland.Drug\u2010related deaths in Scotland in 2023.2024."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0AY00560F"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3119"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2023.2229951"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2021.111140"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkae075"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14060560"},{"key":"e_1_2_10_15_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).New Benzodiazepines in Europe: A Review Lisbon.2021https:\/\/www.euda.europa.eu\/system\/files\/publications\/13759\/TD0221596ENN_002.pdf. Accessed 17 December 2024."},{"key":"e_1_2_10_16_1","unstructured":"European Union Drugs Agency (EUDA).EU Drug Market: New psychoactive substances \u2014 Distribution and supply in Europe: Benzodiazepines. European Union Drugs Agency (EUDA). 2023. Available from:www.euda.eu\/publications\/eu-drug-markets\/new-psychoactive-substances\/distribution-and-supply\/benzodiazepines_en. Accessed 17 December 2024."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.16520"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2023.104245"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550887.2013.824334"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.14108"},{"key":"e_1_2_10_21_1","unstructured":"Coroners Court of Victoria.Victorian overdose deaths 2013\u20132022; 25 January 2024 (revised)."},{"key":"e_1_2_10_22_1","first-page":"176","article-title":"What is drug checking, anyway?","volume":"23","author":"Barratt MJ","year":"2022","journal-title":"Drug Alcohol Depend"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2021.103169"}],"container-title":["Drug and Alcohol Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dar.14054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T07:04:46Z","timestamp":1748415886000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dar.14054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/dar.14054"],"URL":"https:\/\/doi.org\/10.1111\/dar.14054","archive":["Portico"],"relation":{},"ISSN":["0959-5236","1465-3362"],"issn-type":[{"value":"0959-5236","type":"print"},{"value":"1465-3362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,21]]},"assertion":[{"value":"2024-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}