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However, to date, there are no data on the relationships between cannabis and CBD motives. Understanding these relationships and characterising people who co\u2010use cannabis and CBD by their motives can help adapt marketing policies and foster CBD\u2010based harm reduction practices for people who use cannabis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We selected cannabis users from the third wave of the European Web Survey on Drugs conducted in 21 EU and 9 non\u2010EU countries. Using a multilevel mixed\u2010effects logistic regression model, we identified factors associated with CBD co\u2010use. We computed Bonferroni\u2010adjusted tetrachoric correlations between cannabis and CBD self\u2010reported motives for use. We computed Spearman's correlations between the number of declared cannabis and CBD motives. We performed an ascending hierarchical classification to identify cannabis\u2010CBD co\u2010user profiles based on their cannabis and CBD motives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study sample comprised 35,789 participants (42.3% who co\u2010used CBD). CBD use was associated with reporting cannabis therapeutic\u2010oriented motives. The numbers of motives for cannabis and CBD use were correlated (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.49, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Similar motives were highly correlated between substances. Cluster analysis revealed four different co\u2010user profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>Individuals who use both cannabis and CBD tend to do so for similar reasons. Considering the safe profile of CBD, further research should explore the potential harm\u2010reduction role of partially substituting tetrahydrocannabinol\u2010based products with CBD\u2010based products among people who use cannabis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dar.14090","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T22:25:13Z","timestamp":1749421513000},"page":"1666-1679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relationships Between Motives for Cannabis and Cannabidiol Use in People Who Co\u2010Use: Results From the European Web Survey on Drugs"],"prefix":"10.1111","volume":"44","author":[{"given":"Davide","family":"Fortin","sequence":"first","affiliation":[{"name":"Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques &amp; Sociales de la Sant\u00e9 &amp; Traitement de L'information M\u00e9dicale, ISSPAM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Leroy","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques &amp; Sociales de la Sant\u00e9 &amp; Traitement de L'information M\u00e9dicale, ISSPAM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Carrieri","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques &amp; Sociales de la Sant\u00e9 &amp; Traitement de L'information M\u00e9dicale, ISSPAM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Matias","sequence":"additional","affiliation":[{"name":"European Union Drugs Agency  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3439-8868","authenticated-orcid":false,"given":"Tangui","family":"Barr\u00e9","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques &amp; Sociales de la Sant\u00e9 &amp; Traitement de L'information M\u00e9dicale, ISSPAM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,8]]},"reference":[{"issue":"19","key":"e_1_2_9_2_1","article-title":"Cannabis Sativa: The Plant of the Thousand and One Molecules","volume":"7","author":"Andre C. 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