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While hangovers are widely known for their physical symptoms, they also include psychological symptoms such as a depressed mood. These psychological impacts, particularly negative affect (e.g., anxiety, stress), remain less well understood, yet may contribute to maladaptive drinking behaviours and reinforce the cycle of excessive alcohol consumption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach<\/jats:title>\n                    <jats:p>This systematic review, pre\u2010registered and reported in alignment with Preferred Reporting Items for Systematic\u00a0Reviews and Meta\u2010Analyses (PRISMA) and Synthesis without Meta\u2010analysis\u00a0guidelines, aimed to comprehensively examine the association between alcohol hangovers and negative affect. Searches were performed in MEDLINE, Embase, PsycNET, Scopus and CINAHL from inception to January 2025. Two independent reviewers screened articles, assessed the risk of bias and extracted data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Findings<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010two studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096152; mean age 26.9\u2009years, 57% female) demonstrated a significant association between hangovers and increased negative affect, including anxiety, stress and depression. Maladaptive emotional regulation, avoidant coping styles, repetitive negative thinking and greater baseline anxiety exacerbated these negative experiences, while social support and mental resilience offered potential protective factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>The findings highlight the clinical importance of addressing psychological factors in alcohol\u2010related harm. The tendency to return to binge drinking despite negative hangover experiences suggests that psychological factors may perpetuate unhealthy alcohol consumption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review supports a strong link between alcohol hangovers and heightened negative affect. Effective interventions must address both the reduction of negative affect and the underlying drivers of binge drinking to promote healthier alcohol consumption patterns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dar.70052","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T17:00:15Z","timestamp":1761238815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Systematic Review of the Impact of the Alcohol Hangover Upon Negative Affect"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1516-4000","authenticated-orcid":false,"given":"Rebecca","family":"Rothman","sequence":"first","affiliation":[{"name":"Centre for Human Psychopharmacology Swinburne University of Technology  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4470-4718","authenticated-orcid":false,"given":"Amie C.","family":"Hayley","sequence":"additional","affiliation":[{"name":"Centre for Human Psychopharmacology Swinburne University of Technology  Melbourne Australia"},{"name":"Institute for Breathing and Sleep Austin Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-7344","authenticated-orcid":false,"given":"Blair","family":"Aitken","sequence":"additional","affiliation":[{"name":"Centre for Human Psychopharmacology Swinburne University of Technology  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5670-3192","authenticated-orcid":false,"given":"Luke A.","family":"Downey","sequence":"additional","affiliation":[{"name":"Centre for Human Psychopharmacology Swinburne University of Technology  Melbourne Australia"},{"name":"Institute for Breathing and Sleep Austin Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.35946\/arcr.v38.1.05"},{"key":"e_1_2_10_3_1","unstructured":"World Health Organisation \u201cGlobal Status Report on Alcohol and Health 2018 \u201d2024 https:\/\/www.who.int\/publications\/i\/item\/9789241565639."},{"key":"e_1_2_10_4_1","unstructured":"Australian Bureau of Statistics \u201cAlcohol Consumption 2022 | Australian Bureau of Statistics \u201d2024 https:\/\/www.abs.gov.au\/statistics\/health\/health\u2010conditions\u2010and\u2010risks\/alcohol\u2010consumption\/latest\u2010release."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030823"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(93)90017-U"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02181.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041154"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2623"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agm163"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14404"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13010"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agm160"},{"issue":"15","key":"e_1_2_10_14_1","first-page":"2999","article-title":"Effects of Alcohol Hangover on Simulated Highway Driving Performance","volume":"231","author":"Verster J. 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