{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T09:07:57Z","timestamp":1779440877017,"version":"3.53.1"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Issue<\/jats:title>\n                    <jats:p>Alcohol use disorders (AUD) represent a major global health burden, and currently available pharmacological treatments show limited and heterogeneous efficacy. Calcitonin gene\u2010related peptide (CGRP) is a pleiotropic neuropeptide involved in stress regulation and neuroimmune signalling, and is an established therapeutic target in migraine. CGRP signalling may also be involved in alcohol\u2010related mechanisms, raising interest in its potential relevance for AUDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach<\/jats:title>\n                    <jats:p>We conducted a scoping review of original studies investigating CGRP and CGRP\u2010related pathways in the context of alcohol exposure and AUDs. A systematic literature search was performed in PubMed, Embase, Cochrane Library, PsycINFO and Scopus. Animal and human studies published in English were included and synthesised narratively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Findings<\/jats:title>\n                    <jats:p>Thirty studies met the inclusion criteria, including 26 animal studies and 4 human studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>Preclinical evidence indicates that CGRP plays a context\u2010dependent role in AUD\u2010related mechanisms, modulating stress\u2010related drinking, withdrawal\u2010associated adaptations and alcohol\u2010induced nociceptive sensitisation rather than directly driving alcohol consumption. In peripheral tissues, CGRP exerts protective effects against ethanol\u2010induced gastric and pulmonary injury. Human studies were limited and largely observational and showed altered CGRP biology in advanced alcohol\u2010related liver disease, suggesting a compensatory or homeostatic role.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CGRP represents a biologically relevant but complex target in AUDs, with both potential therapeutic and protective roles depending on the clinical context. Anti\u2010CGRP therapies may warrant exploration in carefully selected scenarios, such as alcohol\u2010related headache or stress\u2010associated symptoms during withdrawal in non\u2010cirrhotic patients. Given the homeostatic functions of CGRP, any pharmacological modulation should be cautiously evaluated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dar.70178","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:49:04Z","timestamp":1779191344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Calcitonin Gene\u2010Related Peptide Signalling in Alcohol Use Disorders: A Scoping Review"],"prefix":"10.1111","volume":"45","author":[{"given":"Lanfranco","family":"Pellesi","sequence":"first","affiliation":[{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taibah Ali","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public 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