{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:47:54Z","timestamp":1785754074815,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["SMN\u2010139148"],"award-info":[{"award-number":["SMN\u2010139148"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["SMN\u2010139149"],"award-info":[{"award-number":["SMN\u2010139149"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["SMN\u2010139150"],"award-info":[{"award-number":["SMN\u2010139150"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["SMN\u2010139151"],"award-info":[{"award-number":["SMN\u2010139151"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug and Alcohol Review"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In addition to their use as opioid agonist therapy (OAT), methadone and buprenorphine\/naloxone also have analgesic properties. However, there is limited information on the relative effectiveness of these medications for analgesia in the context of treatment for non\u2010heroin opioid use disorder (OUD). This study estimated the impact of type of OAT on pain among individuals with non\u2010heroin OUD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from OPTIMA, a Canadian, randomised, 24\u2010week clinical trial comparing buprenorphine\/naloxone (via take\u2010home doses) to methadone (via daily witnessed ingestion) for the treatment of non\u2010heroin OUD, we evaluated the impact of type of OAT on pain outcomes (measured by the Brief Pain Inventory) among participants with major pain at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean pain severity scores significantly decreased in both arms over 24\u2009weeks (methadone 4.89\u20132.16, buprenorphine\/naloxone 4.94\u20131.08). There was a time by arm interaction, suggesting better performance of buprenorphine\/naloxone up to week 9, and methadone afterwards. Mean pain\u2010related function scores also significantly decreased over time (methadone 5.31\u20132.70, buprenorphine\/naloxone 5.56\u20133.37), with no significant differences in overall scores between arms (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.675). Methadone was associated with higher odds of achieving both pain severity and pain\u2010related function response at week 24 (30% reduction in pain scores from baseline).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusions<\/jats:title>\n                    <jats:p>Among people with non\u2010heroin OUD initiating OAT, both methadone and buprenorphine\/naloxone were associated with improvements in pain outcomes. However, methadone was associated with a higher likelihood of achieving pain severity and functional treatment response at week 24. These findings suggest the need to consider the type of OAT in the shared\u2010decision making process for people with non\u2010heroin OUD and comorbid pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dar.70190","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:22:03Z","timestamp":1781803323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Impacts of Methadone and Buprenorphine\/Naloxone on Pain\u2010Related Outcomes Among People With Non\u2010Heroin Opioid Use Disorder: Secondary Analyses From a Pragmatic Canadian Multisite Trial"],"prefix":"10.1111","volume":"45","author":[{"given":"Katie","family":"Lyman","sequence":"first","affiliation":[{"name":"Department of Medicine University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinCheol","family":"Choi","sequence":"additional","affiliation":[{"name":"British Columbia Centre on Substance Use  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Jutras\u2010Aswad","sequence":"additional","affiliation":[{"name":"Research Centre, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montreal Canada"},{"name":"Department of Psychiatry and Addictology Faculty of Medicine, Universit\u00e9 de Montr\u00e9al  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Le Foll","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Medicine, University of Toronto  Toronto Canada"},{"name":"Translational Addiction Research Laboratory Centre for Addiction and Mental Health  Toronto Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Canada"},{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9857-9916","authenticated-orcid":false,"given":"Sukhpreet","family":"Klaire","sequence":"additional","affiliation":[{"name":"British Columbia Centre on Substance Use  Vancouver Canada"},{"name":"Division of Addiction Medicine Providence Health Care  Vancouver Canada"},{"name":"Department of Family Practice University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eugenia","family":"Socias","sequence":"additional","affiliation":[{"name":"Department of Medicine University of British Columbia  Vancouver Canada"},{"name":"British Columbia Centre on Substance Use  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.641430"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13011-017-0120-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.01.037"},{"key":"e_1_2_11_5_1","unstructured":"Health Canada \u201cCanadian Pain Task Force Report: March 2021 An action plan for pain in Canada [Internet] \u201d2021 https:\/\/www.canada.ca\/en\/health\u2010canada\/corporate\/about\u2010health\u2010canada\/public\u2010engagement\/external\u2010advisory\u2010bodies\/canadian\u2010pain\u2010task\u2010force\/report\u20102021.html."},{"issue":"12","key":"e_1_2_11_6_1","first-page":"13","article-title":"Significant Factors Associated With Problematic Use of Opioid Pain Relief Medications Among the Household Population, Canada, 2018","volume":"32","author":"Carri\u00e8re G.","year":"2021","journal-title":"Health Reports"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108127"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0211"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4137\/SART.S30120"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.170363"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.170958"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.21090964"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2018.04.001"},{"issue":"2","key":"e_1_2_11_14_1","first-page":"129","article-title":"Pain Assessment: Global Use of the Brief Pain Inventory","volume":"23","author":"Cleeland C. 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