{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:39:32Z","timestamp":1788176372016,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T00:00:00Z","timestamp":1355184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Due to its increased presence in the press and on television, the diagnosis of lipedema is on the way to becoming a trendy diagnosis for those with thick legs. Despite this, one must recognize that lipedema is a very rare disease. It is characterized by disproportional obesity of the extremities, especially in the region of the hip and the legs, hematoma development after minimal trauma, and increased pressure\u2010induced or spontaneous pain. Aids for making the correct diagnosis are (duplex) sonography, the waist\u2010hip index or the waist\u2010height index and lymphoscintigraphy. Important differential diagnoses are constitutional variability of the legs, lipohypertrophy in obesity, edema in immobility, edema in chronic venous insufficiency and rheumatic diseases.<\/jats:p>\n                  <jats:p>The symptom\u2010based therapy of lipedema consists of conservative (compression, manual lymphatic drainage, exercise) and surgical treatments (liposuction). Until now there is no curative therapy. Obesity is an important risk factor for the severity and prognosis of lipedema. Further studies for a better understanding of the pathogenesis of lipedema and in the end possible curative treatments are urgently needed.<\/jats:p>","DOI":"10.1111\/ddg.12024","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T10:33:04Z","timestamp":1355221984000},"page":"225-233","source":"Crossref","is-referenced-by-count":39,"title":["Thick legs \u2013 not always lipedema"],"prefix":"10.1111","volume":"11","author":[{"given":"Stefanie","family":"Reich\u2010Schupke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Altmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"St\u00fccker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,11]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-966651"},{"key":"e_1_2_9_3_2","first-page":"184","article-title":"Lipedema of the legs: A syndrome characterized by fat legs and orthostatic edema","volume":"15","author":"Allen EU","year":"1940","journal-title":"Proc Staff Mayo Clin"},{"key":"e_1_2_9_4_2","first-page":"301","article-title":"Krankheitsspektrum des Lip\u00f6dems an einer lymphologischen Fachklinik \u2013 Erscheinungsformen, Mischbilder und Behandlungsm\u00f6glichkeiten","volume":"5","author":"Herpertz U","year":"1997","journal-title":"Vasomed"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmv.2012.05.002"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01256.x"},{"key":"e_1_2_9_7_2","first-page":"331","volume-title":"Lehrbuch der Lymphologie f\u00fcr Mediziner, Masseure und Physiotherapeuten. 6. 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