{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:30:21Z","timestamp":1787797821202,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T00:00:00Z","timestamp":1384732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Since 2010 the FDA has approved laser systems as capable of producing a \u201ctemporary increase in clear nails\u201d in patients with onychomycosis. Fungal eradication is probably mediated by heat in infrared laser systems; their efficacy has been confirmed thermographically, histologically and in electron microscopy. Another approach to decontaminate the nail organ is to disrupt fungi and spores by q\u2010switched pulse applications. Recently specific combinations of wavelengths have been tested for their ability to disrupt the mitochondrial transmembrane potential at physiological temperatures by generating ATP and ROS. While clinically extremely high clearance rates of approximately 87.5\u201395.8 % have been reported, in\u2010vitro investigations have failed to confirm the clearance. The variety of systems and advised parameters hampers a systematic evaluation. Recommendations for safe and practical treatment protocols, informed consent items, and combination with conventional treatment options are all areas of active work. Currently there is a lack of data concerning the long\u2010term efficacy of laser therapy of onychomycosis; certified treatment protocols are needed.<\/jats:p>","DOI":"10.1111\/ddg.12251","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T00:35:36Z","timestamp":1384821336000},"page":"33-38","source":"Crossref","is-referenced-by-count":11,"title":["Laser therapy of onychomycosis"],"prefix":"10.1111","volume":"12","author":[{"given":"Pietro","family":"Nenoff","sequence":"first","affiliation":[{"name":"Laboratory of Medical Microbiology, partnership Prof. Pietro Nenoff &amp; Dr. Constanze Kr\u00fcger, M\u00f6lbis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Grunewald","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University Leipzig A\u00f6R and Medical Faculty of the University of Leipzig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Paasch","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University Leipzig A\u00f6R and Medical Faculty of the University of Leipzig"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,18]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-012-2448-2"},{"key":"e_1_2_3_3_1","unstructured":"LedonJA SavasJ FrancaKet al.Laser and light therapy for onychomycosis: a systematic review.2012Nov 20. 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[Epub ahead of print]."},{"issue":"12","key":"e_1_2_3_14_1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1610-0387.2012.07997.x","article-title":"Laser treatment of onychomycosis: an in vitro pilot study","volume":"10","author":"Hees H","year":"2012","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.7547\/1020428"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2011.552616"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2009.00615.x"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.7547\/1000166"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-007-0492-4"},{"key":"e_1_2_3_20_1","first-page":"3288","article-title":"Long\u2010pulse Nd:YAG 1064\u2010nm laser treatment for onychomycosis","volume":"125","author":"Zhang RN","year":"2012","journal-title":"Chin Med J;"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-012-0139-3"},{"key":"e_1_2_3_22_1","first-page":"1","article-title":"Novel Laser Therapy in Treatment of Onychomycosis","volume":"2010","author":"Kozarev J","year":"2010","journal-title":"Journal of the Laser and Health Academy"},{"key":"e_1_2_3_23_1","first-page":"S07","article-title":"ClearSteps \u2013 laser onychomycosis treatment: assessment of efficacy 12 month after treatment and beyond","volume":"2011","author":"Kozarev J","year":"2012","journal-title":"Journal of the Laser and Health Academy"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.12251","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.12251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:02:04Z","timestamp":1696345324000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.12251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,18]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/ddg.12251"],"URL":"https:\/\/doi.org\/10.1111\/ddg.12251","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,18]]}}}