{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T19:54:43Z","timestamp":1721246083169},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nd:YAG lasers could be a safe and effective treatment modality for onychomycosis, without the side effects of drugs. Long and short\u2010pulsed Nd:YAG lasers were used in this clinical study in a side\u2010comparison manner without removal of onychomycotic nail material before treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Big toenails of 10 patients were treated twice in a side\u2010comparison manner with the short\u2010pulsed Nd:YAG laser. Fungal cultures were taken and a histological examination was performed before treatment and after 9 months. Two independent investigators rated clearance using the \u201cOnychomycosis Severity Index (OSI)\u201d and standardized photographs at 3\u2010month intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>OSI\u2010Scores decreased for 3.8 (15 %; p = 0.006), 4.8 (19 %; p = 0.0002) and 2.9 points (12 %; p = 0.04) within 3, 6 and 9 months. The positive culture rate at 9 months was significantly reduced to 35 % (p = 0.0003). Classification of severity of onychomycosis showed no change. The difference between the treatment regimens was not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that treatment of onychomycosis with the Nd:YAG laser without removing mycotic nail material can lead to a temporary clinical improvement, a reduction of positive fungal cultures and an improvement of the Onychomycosis Severity Index. The treatment regimen should be optimized to be used as an effective antimycotic monotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12292","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T22:48:32Z","timestamp":1394837312000},"page":"322-329","source":"Crossref","is-referenced-by-count":12,"title":["Treatment of onychomycosis using the 1 064 nm Nd:YAG laser: a clinical pilot study"],"prefix":"10.1111","volume":"12","author":[{"given":"Henrik","family":"Hees","sequence":"first","affiliation":[{"name":"Laserklinik Karlsruhe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Laserklinik Karlsruhe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Raulin","sequence":"additional","affiliation":[{"name":"Laserklinik 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