{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:34:42Z","timestamp":1777476882227,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T00:00:00Z","timestamp":1403049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Germany, notification data cannot be used to determine HIV and syphilis coinfection. No regional cohort has been studied for this in Eastern Germany. The rising incidence of syphilis from 2010 to 2012, predominantly in men having sex with men (MSM), has been suggested as a cause for recent increases in HIV infection rates in this group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Characteristics of 355 consecutive patients newly diagnosed with HIV infection at the University Hospital Dresden 1987\u20132012 were retrospectively compared to German surveillance data from the region of Dresden. Additionally, coinfection with syphilis was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to German surveillance data, we observed higher proportions of persons originating from high prevalence countries and of AIDS cases. In the age group of up to 25 years, the proportion of MSM has risen 3\u2010fold since 2001. At time of HIV diagnosis, seroprevalence of syphilis was 20.3 %. Active syphilis (VDRL \u2265 1: 8) occurred in 6.7 % of patients, predominantly MSM, who also exhibited a significantly higher HIV viral load.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest a causative relationship between recently rising incidences of syphilis and HIV infection in MSM. Early diagnosis of syphilis may promote earlier diagnosis of HIV infection; therefore, HIV prevention measures should also include other sexually transmitted infections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12382","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T14:13:46Z","timestamp":1403100826000},"page":"707-716","source":"Crossref","is-referenced-by-count":14,"title":["Characteristics and coinfection with syphilis in newly HIV\u2010infected patients at the University Hospital Dresden 1987\u20132012"],"prefix":"10.1111","volume":"12","author":[{"given":"Petra","family":"Spornraft\u2010Ragaller","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Carl Gustav Carus, Technical University Dresden  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010Based Healthcare University Hospital Carl Gustav Carus, Technical University Dresden  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Stephan","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010Based Healthcare University Hospital Carl Gustav Carus, Technical University Dresden  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Boashie","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Carl Gustav Carus, Technical University Dresden  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Beissert","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Carl Gustav Carus, Technical University Dresden  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,18]]},"reference":[{"issue":"5","key":"e_1_2_5_2_1","first-page":"363","article-title":"Syphilis and human immunodeficiency virus coinfection","volume":"95","author":"Funnye AS","year":"2003","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_5_3_1","first-page":"213","article-title":"Bericht zur Entwicklung im Jahr 2012 aus dem Robert Koch\u2010Institut","volume":"24","author":"HIV\u2010Infektionen und AIDS\u2010Erkrankungen in Deutschland","year":"2013","journal-title":"Epid Bull"},{"key":"e_1_2_5_4_1","first-page":"457","article-title":"Weiterf\u00fchrende Analysen zur HIV\u2010Inzidenz\u2010 und \u2010Pr\u00e4valenzsch\u00e4tzung 2012","volume":"45","year":"2013","journal-title":"Epid Bull"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2807\/ese.17.29.20222-en","article-title":"Syphilis on the rise again in Germany \u2013 results from surveillance data for 2011","volume":"17","author":"Bremer V","year":"2012","journal-title":"Euro Surveill"},{"key":"e_1_2_5_6_1","first-page":"449","volume":"44","author":"Syphilis in Deutschland 2012","year":"2013","journal-title":"Epid Bull"},{"key":"e_1_2_5_7_1","unstructured":"Syphilis in Deutschland in den Jahren 2010 bis 2011. Epid Bull 48\/2012; 48: 481\u20135."},{"key":"e_1_2_5_8_1","first-page":"465","article-title":"M\u00f6gliche Ursachen f\u00fcr den erneuten Anstieg von HIV\u2010Neuinfektionen bei MSM \u2013 Wechselwirkungen zwischen HIV\u2010 und STI\u2010Koepidemien","volume":"47","author":"Sch\u00e4tzung der Pr\u00e4valenz und Inzidenz von HIV\u2010Infektionen in Deutschland, Stand Ende 2012","year":"2012","journal-title":"Epid Bull"},{"key":"e_1_2_5_9_1","unstructured":"Robert Koch\u2010Institut: Diagramme und Karten zu HIV\/AIDS in Deutschland Erscheinungsdatum 26.11.2012.http:\/\/www.rki.de\/DE\/Content\/InfAZ\/H\/HIVAIDS\/Epidemiologie\/Daten_und_Berichte\/HIV\u2010AIDS\u2010Folien.html."},{"key":"e_1_2_5_10_1","first-page":"7","article-title":"HIV\/AIDS im Freistaat Sachsen \u2013 Jahresbericht 2011","volume":"03","author":"Ehrhard I","year":"2012","journal-title":"LUA\u2010Mitteilungen, Hrsg: Landesuntersuchungsanstalt f\u00fcr das Gesundheits\u2010 und Veterin\u00e4rwesen Sachsen"},{"issue":"36","key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2807\/ese.13.36.18971-en","article-title":"Country\u2010wide HIV incidence study complementing HIV surveillance in Germany","volume":"13","author":"B\u00e4tzing\u2010Feigenbaum J","year":"2008","journal-title":"Euro Surveill"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2010.00857.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-013-0476-1"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2011.00958.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-004-0825-1"},{"key":"e_1_2_5_16_1","unstructured":"http:\/\/www.awmf.org\/uploads\/tx_szleitlinien\/059\u2010002_S1_Diagnostik_und_Therapie_der_Syphilis_07\u20102008_06\u20102012_01.pdf."},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200410210-00012"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000187262.56820.c0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31802ea4c6"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2004.012914"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000199835.95230.4c"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2012.2706"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2005.014555"},{"key":"e_1_2_5_24_1","first-page":"20","article-title":"Sechs Jahre STD\u2010Sentinel\u2010Surveillance in Deutschland \u2013 Zahlen und Fakten","volume":"3","year":"2010","journal-title":"Epid Bull"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2009.040857"},{"issue":"10","key":"e_1_2_5_26_1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/01.olq.0000260919.34598.5b","article-title":"Sexually transmitted infections in Western Europe among HIV\u2010positive men who have sex with men","volume":"34","author":"Dougan S","year":"2007","journal-title":"Sex Transm Dis"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2009.03.004"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-246"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-144"},{"key":"e_1_2_5_30_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2807\/ese.14.48.19426-en","article-title":"STI Study Group and EPI\u2010VIH Group. HIV\/STI co\u2010infection among men who have sex with men in Spain","volume":"14","author":"Diaz A","year":"2009","journal-title":"Euro Surveill"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1071\/SH10053"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000187224.10428.31"},{"key":"e_1_2_5_33_1","first-page":"289","article-title":"Gemeinsame Empfehlung des RKI, der DSTDG *, der DAIG*, der DAGN\u00c4* und der DGHM* Personen mit h\u00e4ufig wechselnden Sexualpartnern sollten spezielle Angebote der Untersuchung auf STD erhalten","volume":"36","year":"2003","journal-title":"Epid Bull"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2011.05.002"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.12382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.12382","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.12382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:36:04Z","timestamp":1696365364000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.12382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,18]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/ddg.12382"],"URL":"https:\/\/doi.org\/10.1111\/ddg.12382","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,18]]}}}