{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:11:17Z","timestamp":1770437477213,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current data from daily practice show that vitamin D<jats:sub>3<\/jats:sub> analogues, corticosteroids and their fixed combination products are used heterogeneously for topical long\u2010term treatment of psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate scientific evidence about topical long\u2010term therapy with vitamin D<jats:sub>3<\/jats:sub> analogues, corticosteroids and their two\u2010compound\u2010products in psoriasis vulgaris and scalp psoriasis and to develop daily practice recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic literature review via PubMed\u00ae and Embase\u00ae and informal expert consensus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search strategy identified 21 relevant clinical trials. Best evidence regarding topical long term treatment was available for the two\u2010compound\u2010formulation containing calcipotriene and betamethasone. In a comparative trial in psoriasis vulgaris the two\u2010compound\u2010formulation showed superior tolerability and cost effectiveness compared to monotherapy. In scalp psoriasis the two\u2010compound\u2010gel was superior compared to calcipotriene monotherapy. Standardized and simplified treatment application modes resulted in a better clinical outcome comparing to on\u2010demand therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Daily practice recommendations<\/jats:title><jats:p>Patients should be proactively involved in the choice of treatment, formulation and mode of application. Besides long\u2010term treatment with the two\u2010compound\u2010formulation other treatment regimens including calcipotriene monotherapy can also be considered. Due to a favorable risk\u2010benefit ratio in maintenance trials and due to better cost\u2010effectiveness the application of two\u2010compound\u2010products once or twice a week after initial therapy is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12396","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T10:08:51Z","timestamp":1405591731000},"page":"667-682","source":"Crossref","is-referenced-by-count":18,"title":["Topical long\u2010term therapy of psoriasis with vitamin D<sub>3<\/sub> analogues, corticosteroids and their two compound formulations: position paper on evidence and use in daily practice"],"prefix":"10.1111","volume":"12","author":[{"given":"Matthias","family":"Augustin","sequence":"first","affiliation":[{"name":"CVderm \u2013 Centre of Excellence for Health Services Research in Dermatology; Institute for Health Services Research in Dermatology and Nursing University Medical Center Hamburg\u2010Eppendorf  Hamburg 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