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In addition to the evidence\u2010 and consensus\u2010based recommendation on the treatment of HE, the guidelines cover mainly consensus\u2010based diagnostic aspects and preventive measures (primary and secondary prevention). Treatment recommendations include non\u2010pharmacological interventions, topical, physical and systemic treatments. Topical corticosteroids are recommended as first line treatment in the management of HE, however continuous long\u2010term treatment beyond six weeks only when necessary and under careful medical supervision. Alitretinoin is recommended as a second line treatment (relative to topical corticosteroids) for patients with severe chronic HE. Randomized control trials (RCT) are missing for other used systemic treatments and comparison of systemic drugs in \u201chead\u2010to\u2010head\u201d RCTs are needed.<\/jats:p><jats:p>The guidelines development group is a working group of the European Society of Contact Dermatitis (ESCD) and has carefully tried to reconcile opposite views, define current optimal practice and provide specific recommendations, and meetings have been chaired by a professional moderator of the AWMF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften; Association of the Scientific Medical Societies in Germany).<\/jats:p><jats:p>No financial support was given by any medical company. The guidelines are expected to be valid until December 2017 at the latest.<\/jats:p>","DOI":"10.1111\/ddg.12510_1","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T15:07:45Z","timestamp":1422371265000},"source":"Crossref","is-referenced-by-count":142,"title":["Guidelines for diagnosis, prevention and treatment of hand eczema"],"prefix":"10.1111","volume":"13","author":[{"given":"Thomas L","family":"Diepgen","sequence":"first","affiliation":[{"name":"Department of Clinical Social Medicine Occupational and Environmental Medicine University Hospital Heidelberg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus E","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Southern Denmark  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Chosidow","sequence":"additional","affiliation":[{"name":"APHP H\u00f4pitaux Universitaires Henri Mondor  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Jan","family":"Coenraads","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Dermatology Unit State University Hospital  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Elsner","sequence":"additional","affiliation":[{"name":"Clinic for Dermatology and Dermatological Allergology University Hospital Jena  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"English","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Nottingham  United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manig\u00e9","family":"Fartasch","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Occupational Dermatology Institute for Prevention and Occupational Medicine Ruhr University Bochum (IPA)  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gimenez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Hospital del Mar Parc de Salut Mar Universitat Autonoma Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Nixon","sequence":"additional","affiliation":[{"name":"Occupational Dermatological Research &amp; Education Center  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Sasseville","sequence":"additional","affiliation":[{"name":"Royal Victoria Hospital  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tove","family":"Agner","sequence":"additional","affiliation":[{"name":"University of Copenhagen Department of Dermatology D Bispebjerg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,27]]},"reference":[{"key":"e_1_2_4_2_1","article-title":"Interventions for hand eczema","author":"Coenraads PJ","year":"2013","journal-title":"Cochrane Database, resubmitted to the Cochrane Database of Systematic Reviews June"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08907.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2010.09094"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01718.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04078.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03361.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01669.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1565"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1984.tb00018.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22406.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.55.11.750"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00731.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08088.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2005.026211"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09822.x"},{"key":"e_1_2_4_17_1","first-page":"117","article-title":"Long term follow\u2010up in atopic dermatitis","volume":"114","author":"Rystedt I","year":"1985","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"e_1_2_4_18_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2340\/000155551871214","article-title":"An epidemiological study of hand eczema. 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