{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T03:07:13Z","timestamp":1721617633885},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T00:00:00Z","timestamp":1420502400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Erythrodermic cutaneous T\u2010cell lymphomas are aggressive diseases posing diagnostic and therapeutic challenges. Numerous indicators for confirming diagnosis and disease\u2010monitoring have been proposed. CD26\u2010negativity of peripheral CD4<jats:sup>+<\/jats:sup> T\u2010cells has been reported to have these properties. Our aim was to test, if the CD4<jats:sup>+<\/jats:sup> T\u2010cell count, fraction of CD26\u2010 or CD7\u2010negative CD4<jats:sup>+<\/jats:sup> T\u2010cells during the course of disease are valuable markers to predict therapeutic efficacy or disease progression in relation to changes in skin status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Retrospective cohort analysis of eleven patients treated at a tertiary referral centre. Statistics were done by linear regression analysis and logrank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients displayed response to therapy in the skin, nine in the blood. Patients with cutaneous response showed a decrease of CD4<jats:sup>+<\/jats:sup> T\u2010cells, preceding the clinical response in most patients, whereas the percentage of CD26\u2010negative T\u2010cells changed first during clinical improvement. The calculated positive predictive values for response or progression were low for both CD4\u2010count and CD26\u2010expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CD26 is not a reliable marker of either response or progression. As cutaneous response was always associated with a response in blood and not vice versa, we conclude, that the clinical status represents the most important parameter for guiding therapeutic decisions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12549","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T12:30:26Z","timestamp":1420547426000},"page":"30-35","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of blood parameters for the monitoring of erythrodermic cutaneous T\u2010cell lymphoma"],"prefix":"10.1111","volume":"13","author":[{"given":"Staffan","family":"Vandersee","sequence":"first","affiliation":[{"name":"Skin cancer centre Charit\u00e9, Department of Dermatology and Allergy, Charit\u00e9 \u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Humme","sequence":"additional","affiliation":[{"name":"Skin cancer centre Charit\u00e9, Department of 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Beyer","sequence":"additional","affiliation":[{"name":"Skin cancer centre Charit\u00e9, Department of Dermatology and Allergy, Charit\u00e9 \u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2006.00541.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.06.014"},{"key":"e_1_2_7_5_1","first-page":"567","article-title":"In situ\u2010demonstration of helper\u2010T\u2010lymphocytes in cutaneous malignant lymphomas by diaminopeptidase IV (DAP IV)","volume":"57","author":"Sterry W","year":"1982","journal-title":"Z 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