{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:08:39Z","timestamp":1788628119554,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T00:00:00Z","timestamp":1426032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are currently no therapeutic guidelines with respect to pyoderma gangrenosum (PG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In order to systematically record currently practiced therapeutic options for PG, a questionnaire was developed and sent to experts at various German dermatology departments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 50 fully completed questionnaires were returned to us. On average, the diagnosis of PG is made 15 times per year. Of these patients, 11.1 % receive only topical therapy; 22.7 %, exclusively systemic therapy; and 66.2 %, both topical and systemic immunomodulatory therapy. Topically, the experts most commonly use class III (78 %) and class IV corticosteroids (88 %). All experts (100 %) reported the frequent use of systemic corticosteroids in the therapy of PG patients. Cyclosporine is used in 74 %, TNF\u2010\u03b1 inhibitors in 24 %, and azathioprine or mycophenolate mofetil each in 20 % of patients. Systemic agents such as dapsone (16 %), intravenous immunoglobulins (14 %), methotrexate (6 %), cyclophosphamide (4 %), tacrolimus (4 %), and rituximab (2 %), however, are given less frequently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Worldwide, no uniformly accepted standard is available for the treatment of patients with PG. In our survey among experts, treatment regimens currently used in Germany, and based on expert clinical experience, have now been recorded, analyzed, and benchmarked for the first time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12585","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T15:59:05Z","timestamp":1426089545000},"page":"317-324","source":"Crossref","is-referenced-by-count":23,"title":["Therapy of pyoderma gangrenosum in Germany: results of a survey among wound experts"],"prefix":"10.1111","volume":"13","author":[{"given":"Philipp","family":"Al Ghazal","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medicine G\u00f6ttingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Dissemond","sequence":"additional","affiliation":[{"name":"Department and outpatient clinic of Dermatology Venereology and Allergology, University Hospital Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2011.07734.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-136"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12401_suppl"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb01568.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90428-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200001000-00004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8351-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013383"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.074815"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.05.028"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1999.00424.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-51"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.168"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03286.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199302000-00005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1242011"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2012.09.004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00104-011-2259-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01212.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327210"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-011-2141-x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-011-2269-8"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488412803305821"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamadermatol.717"},{"key":"e_1_2_10_27_1","article-title":"Vulvovaginal pyoderma gangrenosum secondary to rituximab therapy","author":"Dixit S","year":"2014","journal-title":"J Low Genit Tract Dis"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.78"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.03897.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065843"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2012.12.006"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1167"},{"key":"e_1_2_10_33_1","first-page":"979","article-title":"The use of cyclosporine in dermatology","volume":"11","author":"Dehesa L","year":"2012","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347541201600503"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1005805"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2013.1154"},{"key":"e_1_2_10_37_1","first-page":"1059","article-title":"Treatment of peristomal pyoderma gangrenosum with topical crushed dapsone","volume":"10","author":"Handler MZ","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_10_38_1","first-page":"326","article-title":"Treatment of pyoderma gangrenosum with methotrexate","volume":"57","author":"Teitel AD","year":"1996","journal-title":"Cutis"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.06.003"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31802eb078"},{"key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1684\/ejd.2013.2147","article-title":"Treatment of pyoderma gangrenosum with topical factor XIII","volume":"23","author":"Hoetzenecker W","year":"2013","journal-title":"Eur J Dermatol"},{"key":"e_1_2_10_42_1","first-page":"160","article-title":"Pyoderma gangrenosum treated with sulfasalazine and dapsone","volume":"68","author":"Miranda MF","year":"2002","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.353"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e318278b84c"},{"key":"e_1_2_10_45_1","first-page":"175","article-title":"Treatment of thalidomide resistant pyoderma gangrenosum with etanercept","volume":"20","author":"Guedes R","year":"2012","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_10_46_1","first-page":"297","article-title":"Superficial pyoderma gangrenosum treated with infliximab: a case report","volume":"90","author":"Bhatti H","year":"2012","journal-title":"Cutis"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh479"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2013.1140"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.12585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.12585","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.12585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:34:58Z","timestamp":1696304098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.12585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,11]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/ddg.12585"],"URL":"https:\/\/doi.org\/10.1111\/ddg.12585","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,11]]}}}