{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:42:08Z","timestamp":1756190528758},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Adapalene 0.1\u00a0%\/benzoyl peroxide (BPO) 2.5\u00a0% (Epiduo\u00ae) is the first, fixed\u2010dose topical combination gel developed for the once\u2010daily treatment of acne. The objective of this observational study was to assess efficacy and patient adherence under daily clinical practice conditions in a large population of young adults and adolescents (12 to 20 years) with moderate inflammatory acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A total of 2\u00a0780 patients receiving adapalene\u2010BPO were evaluated in this multicenter, open\u2010label, prospective non\u2010interventional observational study. Observation time per patient was approximately 12 weeks. Assessment parameters included changes in acne severity, treatment success, safety, and therapeutic adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 12 weeks, the majority of patients (91.5\u00a0%) showed improvement of acne under adapalene\u2010BPO treatment, with an initial therapeutic response noted after a median time of 14\u00a0days. Overall, 21.8\u00a0% of participants displayed complete resolution of visible acne lesions. Treatment adherence was assessed as good in 63.2\u00a0% of patients. The majority of individuals (69.5\u00a0%) experienced no or only mild local skin irritations. No serious adverse drug reactions (ADR) were reported during the course of the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adapalene\u2010BPO is effective and safe in the treatment of moderate inflammatory acne. The fixed\u2010dose combination and easy application simplifies the therapeutic regimen, leading to good treatment adherence in the majority of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12613","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T12:18:20Z","timestamp":1432815500000},"page":"557-565","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of adapalene\/benzoyl peroxide combination in moderate inflammatory acne and its impact on patient adherence"],"prefix":"10.1111","volume":"13","author":[{"given":"Harald P. M.","family":"Gollnick","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Otto\u2010von\u2010Guericke University  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Funke","sequence":"additional","affiliation":[{"name":"Hautarztpraxis Waltrop  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kors","sequence":"additional","affiliation":[{"name":"Hautarztpraxis Berlin  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Titzmann","sequence":"additional","affiliation":[{"name":"Hautarztpraxis Augsburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"J\u00f6stingmeyer","sequence":"additional","affiliation":[{"name":"med:unit  K\u00f6ln Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"J\u00e4ckel","sequence":"additional","affiliation":[{"name":"Galderma Laboratorium GmbH  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000165628"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.618"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09209.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.01.001"},{"issue":"5","key":"e_1_2_6_7_1","first-page":"22","article-title":"In\u2010vivo Effectiveness of Adapalene 0.1\u00a0%\/Benzoyl Peroxide 2.5\u00a0% Gel on Antibiotic\u2010sensitive and Resistant Propionibacterium acnes","volume":"4","author":"Leyden JJ","year":"2011","journal-title":"J Clin Aesthet Dermatol"},{"issue":"8","key":"e_1_2_6_8_1","first-page":"898","article-title":"Long\u2010term safety and efficacy of a unique fixed\u2010dose combination gel of adapalene 0.1\u00a0% and benzoyl peroxide 2.5\u00a0% for the treatment of acne vulgaris","volume":"6","author":"Pariser DM","year":"2007","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.006"},{"issue":"2","key":"e_1_2_6_10_1","first-page":"110","article-title":"Adapalene\u2010BPO Study Group. A North American study of adapalene\u2010benzoyl peroxide combination gel in the treatment of acne","volume":"84","author":"Gold L","year":"2009","journal-title":"Cutis"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200607040-00004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.3.337"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2006.00078.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546639809160698"},{"issue":"1","key":"e_1_2_6_15_1","first-page":"17","article-title":"Epiduo Study Group. 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