{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:54:39Z","timestamp":1784818479833,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T00:00:00Z","timestamp":1443225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Secondary squamous cell carcinoma (SCC) is a rare complication of chronic venous leg ulcers. So far, little is known about its pathophysiology and clinical behavior. Initiated by the working group \u201cWound Healing\u201d (AGW) of the German Society of Dermatology (DDG), it is the objective of the current Marjolin registry to collect cases of SCC arising in venous ulcers, in order to evaluate diagnostic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>All members of the AGW received questionnaires inquiring about basic patient data, ulcer characteristics, and therapy conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2010 to 2013, 30 patients (20 women, 10 men) from six tertiary wound care centers were registered. Mean age was 76.17 years. The average duration of venous leg ulcers prior to SCC diagnosis was 15.93 years. Suspicious wound characteristics primarily included: pain (n = 3), therapy resistance (n = 27), and fetor (n = 12) as well as clinical appearance (n = 10) with atypical morphology, nodular wound bed, and hypergranulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Atypical morphology or changes in appearance as well as therapy resistance despite optimal care (6\u201312 weeks) should prompt physicians to take spindle\u2010shaped, if necessary multiple and serial, biopsies. Primary risk factors for malignant transformation include patient age and ulcer duration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12649","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T10:14:56Z","timestamp":1443262496000},"page":"1006-1013","source":"Crossref","is-referenced-by-count":19,"title":["Squamous cell carcinomas in chronic venous leg ulcers. Data of the German Marjolin Registry and review"],"prefix":"10.1111","volume":"13","author":[{"given":"Stefanie","family":"Reich\u2010Schupke","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Vein centre \u2013 Dermatology &amp; Vascular Surgery, Ruhr\u2010University Bochum  Germany"},{"name":"Artemed \u2013 Vein competence centre, Dermatology &amp; Vascular Surgery, Bad Oeynhausen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Doerler","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Vein centre \u2013 Dermatology &amp; Vascular Surgery, Ruhr\u2010University Bochum  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Wollina","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Academic Teaching \u00adHospital Dresden\u2010Friedrichstadt, \u00adDresden  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Dissemond","sequence":"additional","affiliation":[{"name":"Clinic for Dermatology, \u00adVenereology and Allergology, \u00adUniversity Essen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Horn","sequence":"additional","affiliation":[{"name":"Clinic for Dermatology, Venereology and Allergology, Krefeld  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Str\u00f6lin","sequence":"additional","affiliation":[{"name":"Clinic for Dermatology, Venereology and Allergology, University T\u00fcbingen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Erfurt\u2010Berge","sequence":"additional","affiliation":[{"name":"Clinic for Dermatology, Venereology and Allergology, University Erlangen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"St\u00fccker","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Vein centre \u2013 Dermatology &amp; Vascular Surgery, Ruhr\u2010University Bochum  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"496","article-title":"Carcinomatous changes in an area of chronic ulceration, or Marjolin's ulcer","volume":"37","author":"Da Costa JC","year":"1903","journal-title":"Ann Surg"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1990.31.3.234"},{"key":"e_1_2_8_4_1","first-page":"181","article-title":"Marjolin ulcers: secondary carcinomas in chronic wounds","volume":"8","author":"Esther RJ","year":"1999","journal-title":"J South Orthop Assoc"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199303000-00014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2003.08.016"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196603000-00018"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129334-200301000-00014"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(02)00093-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06604.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030000131"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155500750012117"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5070\/D37ZF8466K","article-title":"Squamous cell carcinoma in chronic wound: Marjolin ulcer","volume":"19","author":"Cocchetto V","year":"2013","journal-title":"Dermatol Online J"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2011.00811.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2009.00595.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2013.06.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2011.10.002"},{"key":"e_1_2_8_18_1","first-page":"118","article-title":"Topical treatment of malignant wounds","volume":"3","author":"Wollina U","year":"2001","journal-title":"Eur J Geriatrics"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2340\/0001555573171174","article-title":"Leg ulcers and squamous cell carcinoma. 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