{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:46:17Z","timestamp":1790520377062,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Allergic contact hypersensitivity to metal allergens is a common health concern worldwide, greatly impacting affected individuals with regard to both quality of life and their ability to work. With an estimated 15\u201320\u00a0% of the Western population hypersensitive to at least one metal allergen, sensitization rates for metallic haptens by far outnumber those reported for other common triggers of allergic contact dermatitis such as fragrances and rubber. Unfortunately, the prevalence of metal\u2010induced hypersensitivity remains high despite extensive legislative efforts to ban\/reduce the content of allergy\u2010causing metals in recreational and occupational products.<\/jats:p>\n                  <jats:p>Recently, much progress has been made regarding the perception mechanisms underlying the inflammatory responses to this unique group of contact allergens. This review summarizes recent advances in our understanding of this enigmatic disease. Particular emphasis is put on the mechanisms of innate immune activation and T\u00a0cell activation by common metal allergens such as nickel, cobalt, palladium, and chromate.<\/jats:p>","DOI":"10.1111\/ddg.12673","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T14:15:24Z","timestamp":1433427324000},"page":"653-659","source":"Crossref","is-referenced-by-count":35,"title":["Immunology of metal allergies"],"prefix":"10.1111","volume":"13","author":[{"given":"Marc","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Goebeler","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Hospital W\u00fcrzburg  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