{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:11:12Z","timestamp":1791216672276,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>According to the concept of T\u2010cell plasticity, peripheral T\u00a0cells \u2013 once differentiated into a specific T\u00a0cell subset \u2013 may, in response to new environmental cues or signaling alterations, adopt the phenotype of a different helper cell subset with regard to cytokine production and regulatory functions. In a variety of T\u00a0cell\u2010mediated inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and psoriasis, T\u2010cell plasticity \u2013 in particular the conversion of regulatory T\u00a0cells (Tregs) to IL\u201017\u2010producing inflammatory cells \u2013 has recently been described as key pathomechanism contributing to the aggravation of inflammatory symptoms and disease chronification. Apart from psoriasis, the phenomenon of immune cell plasticity may also have a role in other inflammatory conditions of the skin showing a T\u00a0cell component and\/or an IL\u201017\u2010mediated pathology, such as lichen planus, lupus erythematosus, blistering diseases, allergic disorders, and others. This review summarizes the basic molecular mechanisms regulating T\u2010cell fate decisions and plasticity in inflamed skin and in other lymphoid organs. Moreover, it explores the effect of established targeted therapies as well as alternative concepts with a focus on how to prevent the unwanted conversion of \u201chelpful\u201d T\u00a0cells and other beneficial immune cells to pathological inflammatory vermin.<\/jats:p>","DOI":"10.1111\/ddg.12677","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T22:52:00Z","timestamp":1433976720000},"page":"647-651","source":"Crossref","is-referenced-by-count":5,"title":["T\u2010cell plasticity in inflammatory skin diseases \u2013 the good, the bad, and the chameleons"],"prefix":"10.1111","volume":"13","author":[{"given":"Martina","family":"Gatzka","sequence":"first","affiliation":[{"name":"Department of Dermatology &amp; Allergology University Hospital Ulm  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Scharffetter\u2010Kochanek","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Allergology University Hospital Ulm  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.194"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100123"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300976"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61862"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.139"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202399"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3464"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr078"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075958"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339508786447968"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.04.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302089"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075058"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.12.012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242569"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080034"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100804"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2109"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2013.07.016"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408780111"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-363408"},{"issue":"8","key":"e_1_2_9_25_1","first-page":"888","article-title":"Efficacy, tolerability, and pharmacodynamics of apremilast in recalcitrant plaque psoriasis: a phase II open\u2010label study","volume":"12","author":"Gottlieb AB","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12586"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.12677","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.12677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:23:43Z","timestamp":1696310623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.12677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,8]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/ddg.12677"],"URL":"https:\/\/doi.org\/10.1111\/ddg.12677","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,8]]}}}