{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:04:49Z","timestamp":1770509089379,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Given that there is no standard systemic treatment for children and adolescents with plaque psoriasis, this non\u2010interventional, multicenter, retrospective study collected data on the efficacy and safety of long\u2010term treatment with fumaric acid esters (FAEs) in this particular patient group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>In patients younger than\u00a018\u00a0years of age at the start of FAE treatment, data on efficacy and safety was retrospectively collected for at least 36 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 127 patients (aged 6\u201317 years) was collected for treatment durations of up to 60\u00a0months. Physician's Global Assessment, Psoriasis Area and Severity Index, and Body Surface Area showed marked improvement in the first six months. After 36 months, these parameters had, on average, improved by up to two\u2010thirds of baseline values. Thirty\u2010seven patients experienced at least one adverse event (AE), which was FAE\u2010related in 36 individuals. Three AEs (proteinuria (one case), flushing (two cases)) persisted during the observation period while on treatment. Fifteen AEs led to the discontinuation of therapy; nearly all of these cases were related to gastrointestinal disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The KIDS FUTURE study \u2013 for the first time \u2013 included a larger population of children and adolescents with psoriasis who were treated with FAEs. The data obtained suggests that long\u2010term FAE therapy in this patient group may be effective and safe. The results are currently being verified in an ongoing clinical study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12687","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T14:35:13Z","timestamp":1451399713000},"page":"50-57","source":"Crossref","is-referenced-by-count":13,"title":["Retrospective data collection of psoriasis treatment with fumaric acid esters in children and adolescents in Germany (KIDS FUTURE study)"],"prefix":"10.1111","volume":"14","author":[{"given":"Kristian","family":"Reich","sequence":"first","affiliation":[{"name":"Dermatologikum Hamburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Hartl","sequence":"additional","affiliation":[{"name":"Dermatology\/Allergology Practice  Eltville Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thilo","family":"Gambichler","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology, and Allergology of the Ruhr University  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Zschocke","sequence":"additional","affiliation":[{"name":"SCIderm GmbH Hamburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09593.x"},{"key":"e_1_2_6_3_1","first-page":"11","article-title":"Psoriasis \u2013 new insights into pathogenesis and treatment","volume":"106","author":"Mrowietz U","year":"2009","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S4908"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.12.021"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06343.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.01214.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000232308"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0353.2004.04061.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.07083_supp.x"},{"key":"e_1_2_6_11_1","volume-title":"Etanercept (Enbrel) for moderate\u2010to severe plaque psoriasis in children and adolescents","author":"National Horizon Scanning Centre","year":"2008"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066886"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12102_suppl"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327086"},{"key":"e_1_2_6_15_1","first-page":"28","article-title":"Erfolgreicher Einsatz von Fumars\u00e4ureestern bei einer 14\u2010j\u00e4hrigen Patientin mit Psoriasis vulgaris","volume":"15","author":"Gunther CH","year":"2004","journal-title":"Haut"},{"key":"e_1_2_6_16_1","first-page":"752","article-title":"Therapieerfolg durch Fumars\u00e4ureester bei einem Jugendlichen","volume":"11","author":"Hockmann J","year":"2014","journal-title":"Der Deutsche Dermatologe"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363103"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-010-0085-6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00567.x"},{"key":"e_1_2_6_20_1","first-page":"1","article-title":"Summary of AHRQ's Comparative Effectiveness Review of Disease\u2010Modifying Antirheumatic Drugs for Children with Juvenile Idiopathic Arthritis","volume":"18","author":"McMahan R","year":"2012","journal-title":"J Manag Care Pharm"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200608050-00002"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546\u20100096\u201012\u201013"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2011.07668_suppl.x"},{"key":"e_1_2_6_24_1","unstructured":"Biogen Idec GmbH. 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