{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:06:22Z","timestamp":1769817982931,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T00:00:00Z","timestamp":1448582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>The objective was to determine the diagnostic value of direct immunofluorescence (DIF) in ocular mucous membrane pemphigoid (ocular MMP), taking into account immunofluorescence patterns and biopsy sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>DIF results and medical records of 54 patients with a suspected diagnosis of ocular MMP were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was an overall prevalence of ocular MMP in 70.4 % of cases. Linear deposition of IgA, IgG, or C3 showed a high positive predictive value (84\u2013100 %). Sensitivity and negative predictive value of IgG, IgM, IgG, and C3 in DIF were higher in cutaneous samples than in conjunctival biopsies, thus yielding a higher diagnostic accuracy. The sensitivity of DIF in ocular MMP seems to be lower than in bullous pemphigoid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The diagnostic value of DIF in the workup of ocular MMP was confirmed. However, biopsies taken from non\u2010conjunctival, cutaneous tissue appear to yield more accurate results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12716","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T13:03:59Z","timestamp":1448629439000},"page":"1268-1274","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic relevance of direct immunofluorescence in ocular mucous membrane pemphigoid"],"prefix":"10.1111","volume":"13","author":[{"given":"Tarun","family":"Mehra","sequence":"first","affiliation":[{"name":"Department of Dermatology, Eberhard\u2010Karls\u2010University  T\u00fcbingen Germany"},{"name":"Medical Directorate, University Hospital of Zurich, R\u00e4mistrasse 100  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuella","family":"Guenova","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Eberhard\u2010Karls\u2010University  T\u00fcbingen 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