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Patient age ranged from 18 to 96 years (mean 59.8). Wound size varied from 1\u2013600\u00a0cm\u00b2 (mean 65.6\u00a0cm\u00b2), and the pain intensity was predominantly very high (VAS 1\u201310, mean 7). The lower legs were most commonly (71.9\u00a0%) affected. Overall, 12 (9.9\u00a0%) patients had inflammatory bowel disease (ulcerative colitis, 5.8\u00a0%; Crohn's disease, 4.1\u00a0%), 14.1\u00a0% exhibited rheumatic comorbidities. Neoplasms were found in 20.6\u00a0% of patients, with 6.6\u00a0% classified as hematological and 14.0\u00a0% as solid neoplasms. With respect to criteria for the metabolic syndrome, obesity was found in 69.4\u00a0%, arterial hypertension in 57.9\u00a0%, and diabetes mellitus in 33.9\u00a0% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present data analysis confirms the association of PG with metabolic syndrome and neoplasms. In the future, these aspects should be included in the targeted diagnostic workup of patients with PG and subsequently treated in a timely fashion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12791","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T16:38:52Z","timestamp":1477067932000},"page":"1023-1030","source":"Crossref","is-referenced-by-count":7,"title":["Tricenter analysis of cofactors and comorbidity in patients with pyoderma gangrenosum"],"prefix":"10.1111","volume":"14","author":[{"given":"Finja","family":"Jockenh\u00f6fer","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology, and Allergology University Hospital Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Herberger","sequence":"additional","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing\/Comprehensive Wound Center (CWC) University Medical Center Hamburg 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