{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T09:41:46Z","timestamp":1696412506544},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Einleitung<\/jats:title><jats:p>Das Pyoderma gangraenosum (PG) ist eine seltene, inflammatorische destruktiv\u2010ulzerierende neutrophile Erkrankung mit weitgehend unklarer Pathophysiologie.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material und Methodik<\/jats:title><jats:p>In dieser Studie wurden die potenziell relevanten Kofaktoren und Begleiterkrankungen von Patienten mit PG aus drei dermatologischen Wundzentren in Deutschland differenziert ausgewertet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Von den insgesamt 121 analysierten Patienten waren Frauen (66,9\u00a0%) h\u00e4ufiger betroffen als M\u00e4nner. Das Alter der Patienten war 18\u201396 Jahre (Mittelwert [MW]: 59,8); die Wunden hatten eine Gr\u00f6\u00dfe von 1\u2013600\u00a0cm\u00b2 (MW: 65,6\u00a0cm\u00b2) und waren \u00fcberwiegend sehr schmerzhaft (VAS 1\u201310, MW: 7). Die Unterschenkel waren am h\u00e4ufigsten (71,9\u00a0%) betroffen. Bei 12 (9,9\u00a0%) Patienten bestanden chronisch entz\u00fcndliche Darmerkrankungen (5,8\u00a0% Colitis ulcerosa; 4,1\u00a0% Morbus Crohn), bei 14,1\u00a0% der Patienten wurde eine Begleiterkrankung aus dem rheumatischen Formenkreis beschrieben. Neoplasien bestanden bei 20,6\u00a0% der Patienten, von denen 6,6\u00a0% als h\u00e4matologische und 14,1\u00a0% als solide Neoplasien klassifiziert wurden. Aus dem Kreis des metabolischen Syndroms wurde bei 69,4\u00a0% Patienten eine Adipositas, bei 57,9\u00a0% eine arterielle Hypertonie und bei 33,9\u00a0% ein Diabetes mellitus diagnostiziert.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen<\/jats:title><jats:p>Diese Datenanalyse best\u00e4tigt Assoziationen des PG mit dem metabolischen Syndrom und mit Neoplasien, die zuk\u00fcnftig fr\u00fchzeitig bei einer zielgerichteten Diagnostik der Patienten beachtet und behandelt werden sollten.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12791_g","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T16:38:52Z","timestamp":1477067932000},"page":"1023-1031","source":"Crossref","is-referenced-by-count":3,"title":["Trizentrische Analyse von Kofaktoren und Komorbidit\u00e4t des Pyoderma gangraenosum"],"prefix":"10.1111","volume":"14","author":[{"given":"Finja","family":"Jockenh\u00f6fer","sequence":"first","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie, Venerologie und Allergologie Universit\u00e4tsklinikum Essen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Herberger","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Versorgungsforschung in der Dermatologie und bei Pflegeberufen\/Universit\u00e4res Wundzentrum (CWC) Universit\u00e4tsklinikum Hamburg\u2010Eppendorf  Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Schaller","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie, Allergologie und Phlebologie Helios Kliniken Duisburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja Christina","family":"Hohaus","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie, Venerologie und Allergologie Universit\u00e4tsklinikum Essen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren","family":"Stoffels\u2010Weindorf","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie, Venerologie und Allergologie Universit\u00e4tsklinikum Essen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Al Ghazal","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie, Venerologie und Allergologie Universit\u00e4tsklinikum G\u00f6ttingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Augustin","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie, Allergologie und Phlebologie Helios Kliniken Duisburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Dissemond","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie, Venerologie und Allergologie Universit\u00e4tsklinikum Essen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-19"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2006.06052.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-136"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/ddg.12401","article-title":"Diagnostic criteria for pyoderma gangrenosum: results of a survey among dermatologic wound experts in Germany","volume":"12","author":"Al Ghazal P","year":"2014","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03199.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.61.718.689"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2011.00750.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2011.07734.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.20022083.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12585"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0901-777"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-331462"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.10.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01329.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.130"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200001000-00004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10565.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05408.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.03988.x"},{"key":"e_1_2_8_21_1","unstructured":"Deutsche Morbus Crohn\/ Colitis ulcerosa Vereinigung:http:\/\/www.dccv.de\/crohn\u2010colitis\/medizinische\u2010grundlagen\/faq\u2010haeufig\u2010gestellte\u2010fragen\/was\u2010ist\u2010eine\u2010chronisch\u2010entzuendliche\u2010darmerkrankung\u2010ced\/#irfaq_5_c0a36[Letzter Zugriff: 20.05.2015]."},{"key":"e_1_2_8_22_1","first-page":"173","article-title":"Pyoderma gangrenosum: a review of 86 patients","volume":"55","author":"Powell FC","year":"1985","journal-title":"Q J Med"},{"key":"e_1_2_8_23_1","unstructured":"Crohn's and Colitis Foundation of America:http:\/\/www.ccfa.org\/what\u2010are\u2010crohns\u2010and\u2010colitis\/what\u2010is\u2010ulcerative\u2010colitis[Letzter Zugriff: 20.05.2015]."},{"key":"e_1_2_8_24_1","unstructured":"GEKID Gesellschaft der epidemiologischen Krebsregister Deutschland 2014:http:\/\/www.gekid.de\/Atlas\/CurrentVersion\/Help\/Ergebnisse%20GEKID%20Atlas%20Deutschland_2014.pdf[Letzter Zugriff: 20.05.2015]."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08211.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-010-8248-5"},{"key":"e_1_2_8_27_1","unstructured":"Universit\u00e4t Leipzig IFB Adipositas Erkrankungen:http:\/\/www.ifb\u2010adipositas.de\/presse\/adipositas\u2010zahlen[Letzter Zugriff: 20.05.2015]."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)10187-8"},{"key":"e_1_2_8_29_1","unstructured":"Centers for Disease Control and Prevention 2010:http:\/\/www.cdc.gov\/nchs\/data\/series\/sr_10\/sr10_252.pdf[Letzter Zugriff: 20.05.2015]."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2007-0462"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00930.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-013-1669-6"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.009"},{"key":"e_1_2_8_34_1","unstructured":"Diabetesstiftung Gesundheitsbericht 2011:http:\/\/www.diabetesstiftung.de\/uploads\/media\/Gesundheitsbericht_2011.pdf[Letzter Zugriff: 20.05.2015]."},{"key":"e_1_2_8_35_1","unstructured":"DDZ Deutsches Diabetes\u2010Zentrum:http:\/\/www.diabetes\u2010heute.uni\u2010duesseldorf.de\/fachthemen\/sonstiges\/?TextID=929#1[Letzter Zugriff: 20.05.2015]."},{"key":"e_1_2_8_36_1","first-page":"1839","article-title":"Chronic inflammation and atherosclerosis","volume":"138","author":"Hundelshausen P","year":"2013","journal-title":"Dtsch Med Wochenschr"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1242011"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328341152f"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.017"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09404.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.12.025"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0929-7"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.12791_g","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.12791_g","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.12791_g","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:38:43Z","timestamp":1696315123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.12791_g"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/ddg.12791_g"],"URL":"https:\/\/doi.org\/10.1111\/ddg.12791_g","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]}}}