{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:19:14Z","timestamp":1696396754857},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T00:00:00Z","timestamp":1446076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>The increase in minimum inhibitory concentrations (MICs) of cephalosporins for <jats:italic>Neisseria gonorrhoeae<\/jats:italic> has given rise to concerns regarding potentially untreatable gonococcal infections. The goal was to ascertain the prevalence of gonorrhea in a Viennese patient group and determine resistance patterns. Another objective was to evaluate resistance profiles and MIC values of gonococcal isolates in an Austria\u2010wide surveillance project.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>From 1999 to 2014, 350,000 individuals were tested for gonococci at the Viennese Outpatient Clinic. In addition, from 2010 to 2014, the MICs of recommended antibiotics was determined in 3,584 gonococcal isolates, initially by agar dilution and breakpoint determination, and, from 2012 onwards, by Etest\u00ae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the observation period, the prevalence of gonorrhea increased eightfold, with a significantly greater number of quinolone, penicillin, and tetracycline\u2010 resistant strains. In gonococcal strains isolated from across Austria, there was an increase in cefixime and ceftriaxone MICs toward breakpoints. Twenty\u2010one isolates showed cefixime resistance, and while there was an increase in azithromycin resistance from 0.9 % (2013) to 3.2 % (2014), no resistance to ceftriaxone was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Currently, there is no imminent risk of untreatable gonorrhea in Austria. However, continuing the use of gonococcal cultures as a diagnostic tool for establishing resistance profiles is essential in order to monitor trends in the development of <jats:italic>Neisseria (N.) gonorrhoeae<\/jats:italic> resistance.<\/jats:p><\/jats:sec><\/jats:sec>","DOI":"10.1111\/ddg.12816","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T16:58:12Z","timestamp":1446137892000},"page":"1136-1145","source":"Crossref","is-referenced-by-count":0,"title":["Gonococcal infections in Austria: a long\u2010term observation of prevalence and resistance profiles from 1999 to 2014"],"prefix":"10.1111","volume":"13","author":[{"given":"Angelika","family":"Stary","sequence":"first","affiliation":[{"name":"Outpatient Clinic and Other Venereal\/Dermatologic Diseases  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Heller\u2010Vitouch","sequence":"additional","affiliation":[{"name":"Outpatient Clinic and Other Venereal\/Dermatologic Diseases  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Binder","sequence":"additional","affiliation":[{"name":"Outpatient Clinic for the Diagnosis and Treatment of Sexually Transmitted Diseases \u2013 Municipal Department 15  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Geusau","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy, and Infectious Diseases, Department of Dermatology University Medical Center Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Stary","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy, and Infectious Diseases, Department of Dermatology University Medical Center Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klemens","family":"Rappersberger","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Rudolfstiftung Hospital  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Komericki","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Medical Center Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Hoepfl","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Medical Center Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Haller","sequence":"additional","affiliation":[{"name":"Outpatient Clinic and Other Venereal\/Dermatologic Diseases  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/ddg.12310","article-title":"Sexually transmitted infections","volume":"12","author":"Fuchs W","year":"2014","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0353.2004.04027.x-i1"},{"key":"e_1_2_6_4_1","volume-title":"Global incidence and prevalence of selected curable sexually transmitted infection \u2013 2008","author":"World Health Organization (WHO)","year":"2012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00010-14"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00325-11"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2014.19.45.20955"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2012-050909"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2013-051117"},{"issue":"1","key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2340\/00015555537580","article-title":"Culture diagnosis of gonorrhea: A comparison of the yield with selective and non\u2010selective gonococcal culture media inoculated in the clinic and after treatment of specimens","volume":"53","author":"Danielsson D","year":"1973","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2307\/4592051"},{"key":"e_1_2_6_12_1","unstructured":"CLSI Performance Standards for Antimicrobial Susceptibility Testing; Eighteenth Informational Supplement CLSI document M100\u2010S18 Wayne PA: Clinical and Laboratory Standards Institute; 2008."},{"key":"e_1_2_6_13_1","unstructured":"World Health Organization. Global action plan to control the spread and impact of antimicrobial resistance inNeisseria gonorrhoeae. Available at:http:\/\/www.who.reproductivehealth\/publications\/rtis\/9789241503501\/en\/.Assessed October 2 2014."},{"key":"e_1_2_6_14_1","unstructured":"ECDC Surveillance Report 2012.Gonococcal antimicrobial susceptibility surveillance in Europe European Centre for Disease Prevention and Control. Gonococcal antimicrobial susceptibility surveillance in Europe 2012. Stockholm: ECDC; 2014."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000185"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2013.18.33.20560"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2012-050663"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462412472837"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1610-0387.2012.08044.x","article-title":"Gonorrhea: Data on antibiotic resistance and accompanying infections at the University Hospital Dresden over a 10\u2010year time period","volume":"11","author":"Abraham S","year":"2013","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199403000-00010"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3182631c9f"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2014.19.44.20951"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000279"},{"key":"e_1_2_6_24_1","first-page":"1","article-title":"Sexually Transmitted Diseases Treatment Guidelines, 2015","volume":"64","author":"Centers for Disease Control and Prevention","year":"2015","journal-title":"MMWR"},{"issue":"43","key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"pii: 19998","DOI":"10.2807\/ese.16.43.19998-en","article-title":"First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011","volume":"16","author":"Unemo M","year":"2011","journal-title":"Euro Surveill"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.100397"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2011.11.010"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05760-11"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.10.020"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.12816","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.12816","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.12816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:11:26Z","timestamp":1696363886000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.12816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,29]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/ddg.12816"],"URL":"https:\/\/doi.org\/10.1111\/ddg.12816","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,29]]}}}