{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:40:56Z","timestamp":1791229256704,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on the efficacy of acne treatments and their impact on quality of life (QoL) in adult patients is sketchy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Assessment of the efficacy of azelaic acid 20\u00a0% cream (Skinoren<jats:sup>\u00ae<\/jats:sup>) on acne severity and disease\u2010related QoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Noninterventional study in adult female patients with mild to moderate acne. Efficacy variables included DLQI and acne severity on the face, chest, and back using the Investigator's Global Assessment (IGA) scale (grade\u00a01\u00a0=\u00a0nearly clear skin; 2\u00a0=\u00a0mild acne; 3\u00a0=\u00a0moderate acne). Visits were scheduled at baseline, at 4\u20138 weeks, and at twelve weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 251 women enrolled, 59\u00a0% had grade 1 acne at baseline; 31\u00a0%, grade 2; and 10\u00a0%, grade 3; the most commonly affected area of the body was the face (IGA grades\u00a02 or 3: 79\u00a0%). After twelve weeks, there was significant improvement of acne on the face (IGA grades\u00a00 or 1: 82\u00a0%), chest, and back. Median DLQI decreased from nine at baseline to five after twelve weeks. Ninety percent of physicians and patients rated the tolerability of the treatment as very good or good.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with azelaic acid 20\u00a0% cream significantly improves acne severity and disease\u2010related QoL in adult women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12889","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T12:57:06Z","timestamp":1480424226000},"page":"1249-1259","source":"Crossref","is-referenced-by-count":11,"title":["Azelaic acid 20\u00a0% cream: effects on quality of life and disease severity in adult female acne patients"],"prefix":"10.1111","volume":"14","author":[{"given":"Julius Thomas","family":"Kainz","sequence":"first","affiliation":[{"name":"Dermatology Practice  8430 Leibnitz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Berghammer","sequence":"additional","affiliation":[{"name":"Medical Writer 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