{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T05:14:25Z","timestamp":1693804465114},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To present information on the frequency of drug\u2010drug interactions and adverse drug reactions, and to provide assistance on how to minimize these major problems in the pharmacological treatment of dermatological inpatients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>The medications given to 1,099 dermatological inpatients were retrospectively analyzed for drug\u2010drug interactions and adverse drug reactions using web\u2010based drug interaction software (Diagnosia<jats:sup>\u00ae<\/jats:sup> Check).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We report an overall frequency of relevant drug\u2010drug interactions of 51.7\u00a0%, with an average of 3.2 interactions per affected inpatient. Drug combinations that should have been avoided were found in 5.7\u00a0% of the study population. Total drug count was the most important risk factor. Drug groups involved in the majority of interactions were analgesics, cardiovascular and antithrombotic agents, as well as antidepressants. The risk of developing adverse drug reactions was rated as \u201chigh\u201d in 53.1\u00a0% of inpatients. The top five adverse reactions in this patient group were bleeding, constipation, anticholinergic effects, sedation, and orthostatic effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Potential drug\u2010drug interactions as well as adverse drug reactions are alarmingly common in dermatological inpatients. Every other patient is at risk of experiencing such interactions or adverse reactions, and every twentieth patient receives a drug combination that should not be administered. Increased alertness is a must in order to identify patients at risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.12915","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T16:53:47Z","timestamp":1479920027000},"page":"1122-1129","source":"Crossref","is-referenced-by-count":1,"title":["Potential drug\u2010drug interactions and adverse drug reactions in dermatological inpatients"],"prefix":"10.1111","volume":"14","author":[{"given":"Lukas","family":"Koch","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical University of Graz  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birger","family":"Kr\u00e4nke","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Graz  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Aberer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Graz  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