{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:11:07Z","timestamp":1696320667510},"reference-count":76,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Der \u00fcberm\u00e4\u00dfige oder unkritische weltweite Einsatz von Antibiotika in der Medizin hat die Ausbreitung von Antibiotikaresistenzen beschleunigt. In einigen Bereichen sind viele Antibiotika bei bakteriellen Infektionen, die zuvor noch gut auf antibakterielle Wirkstoffe reagierten, mittlerweile wirkungslos geworden. Dermatologen\/Venerologen setzten orale und topische Antibiotika bei der Behandlung von Acne vulgaris routinem\u00e4\u00dfig ein, obwohl Akne weder eine infekti\u00f6se Erkrankung ist noch alleine durch das <jats:italic>Propionibacterium<\/jats:italic> getriggert wird. Vielmehr ist sie eine komplexe, chronische entz\u00fcndliche Hauterkrankung, die durch verschiedene pathogenetische Faktoren wie follikul\u00e4re Hyperkeratose, erh\u00f6hter Sebumproduktion, bakterielle Proliferation und Entz\u00fcndung zustande kommt. Folglich sollte eine erfolgreiche Therapie auf die Bek\u00e4mpfung verschiedener pathogenetischer Faktoren und nicht nur auf die von <jats:italic>Propionibacterium acnes<\/jats:italic> abzielen. Daher wurden topische Retinoide und Benzoylperoxid als Mittel der ersten Wahl definiert. Monotherapien mit lokalen Antibiotika sollten insgesamt vermieden werden. Systemische Antibiotika der Tetrazyklin\u2010Gruppe haben bei bestimmen Krankheitsstadien ihren Sinn, ihre Wirkung k\u00f6nnte aber eher auf der antientz\u00fcndlichen als auf der antibiotischen Reaktion beruhen. Gesundheitsbeh\u00f6rden ermahnen alle Gesundheitsdienstleister, den Einsatz von Antibiotika einzuschr\u00e4nken. Das Nutzen\u2010Risiko\u2010Verh\u00e4ltnis muss bei der Entscheidung f\u00fcr oder gegen eine antibiotische Therapie bei einem einzelnen Patienten immer auch in Bezug auf das \u00f6ffentliche Interesse am Erhalt der Wirksamkeit von Antibiotika abgewogen werden. Im Folgenden werden das aktuelle Krankheitskonzept zu Acne vulgaris und die sich daraus ableitenden Konsequenzen f\u00fcr den Einsatz von Antibiotika vorgestellt.<\/jats:p>","DOI":"10.1111\/ddg.13048","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T16:00:46Z","timestamp":1482163246000},"page":"1319-1327","source":"Crossref","is-referenced-by-count":1,"title":["Verantwortlicher Umgang mit Antibiotika: Notwendigkeit der Antibiotikareduktion in der Aknetherapie"],"prefix":"10.1111","volume":"14","author":[{"given":"Harald P. M.","family":"Gollnick","sequence":"first","affiliation":[{"name":"Magdeburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Buer","sequence":"additional","affiliation":[{"name":"Essen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Beissert","sequence":"additional","affiliation":[{"name":"Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cord","family":"Sunderk\u00e4tter","sequence":"additional","affiliation":[{"name":"M\u00fcnster"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0804651"},{"key":"e_1_2_12_3_1","volume-title":"Antimicrobial resistance: global report on surveillance","author":"World Health Organization","year":"2014"},{"issue":"10","key":"e_1_2_12_4_1","first-page":"1244","article-title":"Federal Institute for Drugs and Medical Devices (BfArM). Hygiene requirements for the reprocessing of medical devices. Recommendation of the commission for hospital hygiene and Infection prevention (KRINKO) at the Robert Koch Institute (RKI) and the Federal Institute for Drugs and Medical Devices (BfArM)","volume":"55","author":"Commission for Hospital Hygiene and Infection Prevention (KRINKO)","year":"2012","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12488"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2011.07786_suppl.x"},{"key":"e_1_2_12_7_1","volume-title":"f\u00fcr die Expertenkommission der Paul\u2010Ehrlich\u2010Gesellschaft f\u00fcr Chemotherapie e.V. Empfehlungen zur kalkulierten parenteralen Initialtherapie bakterieller Erkrankungen bei Erwachsenen \u2013 Update 2016 GMS\u2010Infectious Diseases 2017","author":"Sunderk\u00f6tter C"},{"issue":"2","key":"e_1_2_12_8_1","first-page":"118","article-title":"A status report on the use of subantimicrobial\u2010dose doxycycline: a review of the biologic and antimicrobial effects of the tetracyclines","volume":"74","author":"Del Rosso JQ.","year":"2004","journal-title":"Cutis"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464210-00002"},{"issue":"6","key":"e_1_2_12_10_1","first-page":"655","article-title":"The development of antimicrobial resistance due to the antibiotic treatment of acne vulgaris: a review","volume":"9","author":"Patel M","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000424238"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)70005-8"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05067.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"},{"issue":"2","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1001\/archderm.1971.04000140034006","article-title":"Ecological effects of oral antibiotics on the microflora of human skin","volume":"103","author":"Marples RR","year":"1971","journal-title":"Arch Dermatol"},{"issue":"6","key":"e_1_2_12_16_1","first-page":"655","article-title":"The development of antimicrobial resistance due to the antibiotic treatment of acne vulgaris: a review","volume":"9","author":"Patel M","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-99-6-834"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-22-4-285"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0195941700067278"},{"key":"e_1_2_12_20_1","first-page":"225","article-title":"Skin as a source of transferable antibiotic resistance in coagulase\u2010negative staphylococci","volume":"16","author":"Naidoo J","year":"1987","journal-title":"Zentralblatt Bakt Suppl"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155502320323216"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/379619"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708143370701"},{"issue":"6","key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1128\/JCM.37.6.1727-1731.1999","article-title":"Characterization of antimicrobial resistance in Streptococcus pyogenes isolates from the San Francisco Bay area of northern California","volume":"37","author":"York MK","year":"1999","journal-title":"J Clin Microbiol"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13783"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12721"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2010.07466.x"},{"issue":"12","key":"e_1_2_12_28_1","first-page":"1331","article-title":"A call to limit antibiotic use in acne","volume":"12","author":"Thiboutot D","year":"2013","journal-title":"J Drugs Dermatol"},{"issue":"3","key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1684\/ejd.2014.2309","article-title":"Antibiotic stewardship in dermatology: limiting antibiotic use in acne","volume":"24","author":"Dreno B","year":"2014","journal-title":"Eur J Dermatol"},{"key":"e_1_2_12_30_1","volume-title":"A dictionary of epidemiology. 4th ed","author":"Last J M.","year":"1988"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200809050-00001"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13190"},{"issue":"5","key":"e_1_2_12_33_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jdv.13186","article-title":"From new findings in acne pathogenesis to new approaches in treatment","volume":"29","author":"Gollnick HP.","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.029"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700213"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.4919"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04602.x"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10897.x"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02734.x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.05.013"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm408"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.29219-0"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12159"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.400"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.505"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.012"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab2009"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2154"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107908"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-02202-9_143"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012277"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1794"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12224"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.08.001"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00552.x"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01339.x"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70050-1"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.618"},{"issue":"6","key":"e_1_2_12_59_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/ddg.12613","article-title":"Efficacy of adapalene\/benzoyl peroxide combination in moderate inflammatory acne and its impact on patient adherence","volume":"13","author":"Gollnick HP","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13194"},{"issue":"9","key":"e_1_2_12_61_1","first-page":"899","article-title":"Long\u2010term safety and efficacy of a unique fixed\u2010dose combination gel of adapalene 0.1 % and benzoyl peroxide 2.5 % for the treatment of acne vulgaris","volume":"6","author":"Pariser DM","year":"2007","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2007.02.001"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01962381"},{"key":"e_1_2_12_64_1","first-page":"210","article-title":"Topical quinolone OPC\u20107251: a clinical and microbiological study in acne","volume":"4","author":"Gollnick HPM","year":"1994","journal-title":"Eur J Dermatol"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.553192"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP201650"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.01.048"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.4.459"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.5.768"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374980120011601"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00840.x"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.9.1472"},{"issue":"2","key":"e_1_2_12_73_1","first-page":"94","article-title":"Effective and safe combination therapy for severe acne vulgaris: a randomized, vehicle\u2010controlled, double\u2010blind study of adapalene 0.1 %\u2010benzoyl peroxide 2.5 % fixed\u2010dose combination gel with doxycycline hyclate 100 mg","volume":"85","author":"Gold LS","year":"2010","journal-title":"Cutis"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-001-0334-4"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.004"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.6.3.409"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2008.07.003"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.13048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.13048","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.13048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:29:20Z","timestamp":1696282160000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.13048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":76,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/ddg.13048"],"URL":"https:\/\/doi.org\/10.1111\/ddg.13048","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}