{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:00:57Z","timestamp":1777550457972,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T00:00:00Z","timestamp":1467590400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Components of oxidative hair dyes, such as p\u2010toluylenediamine, are very potent contact sensitizers to which many consumers as well as hairdressers and their clients are commonly exposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on the qualitative composition of both retail and professional haircare products as determined by package labeling (according to INCI), we conducted a survey on the exposure to active components of oxidative hair dyes in Germany. The joint occurrence of components is also discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nearly all of the 20 most commonly used substances are potent or very potent contact sensitizers. Contained in 88\u00a0% of all products, p\u2010toluylenediamine is the most common component. There are only minor differences between retail and professional products. A frequent combination of substances includes p\u2010toluylenediamine (sulfate), resorcinol as well as m\u2010aminophenol. However, their actual concentrations (which were not investigated in this study) may vastly differ depending on the shade of the individual hair dye.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Descriptive univariate analysis reveals that the currently used patch test series \u201cHairdressing Chemicals\u201d, as recommended by the German Contact Allergy Research Group (DKG), does not adequately cover the spectrum of allergens consumers and professionals are exposed to. Other studies have also suggested that a number of other allergens should be tested as well. Taking into account the dynamic kinetics of oxidative hair dyes with respect to allergy development, the effects of combined simultaneous exposure to multiple allergens on the risk of sensitization requires further research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.13099","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T06:06:46Z","timestamp":1467612406000},"page":"707-715","source":"Crossref","is-referenced-by-count":16,"title":["Survey of sensitizing components of oxidative hair dyes (retail and professional products) in Germany"],"prefix":"10.1111","volume":"14","author":[{"given":"Stephan","family":"Kirchlechner","sequence":"first","affiliation":[{"name":"Institute for Medical Informatics, Biometry, and Epidemiology University of Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Environmental Medicine, and Health Theory University of Osnabruck  Osnabruck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Uter","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry, and Epidemiology University of Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,4]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"SCCS (Scientific Committee on Consumer Safety) memorandum on hair dye chemical sensitisation 26 February 2013 Scientific Committee on Consumer Safety Brussels ISBN 978\u201092\u201079\u201030078\u20103."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06588.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12196"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01916.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13412"},{"key":"e_1_2_6_7_1","article-title":"Survey and occurrence of PPD, PTD and other allergenic hair dye substances in hair dyes","author":"Brunn Poulsen P","year":"2013","journal-title":"The Danish Environmental Protection Agency"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01612.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01979.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12164"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01945.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12676"},{"issue":"690","key":"e_1_2_6_13_1","first-page":"692","article-title":"Optimierte Versorgung von Patienten mit berufsbedingten Handekzemen: Hautarztverfahren und Stufenverfahren Haut der gesetzlichen Unfallversicherung","volume":"59","author":"Skudlik C","year":"2008","journal-title":"Hautarzt"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01547.x"},{"key":"e_1_2_6_15_1","first-page":"98","article-title":"Die routinem\u00e4\u00dfige Vortestung von Produkten mit oxidativen Haarfarben vor dem Haaref\u00e4rben ist problematisch und wird abgelehnt. 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