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The disorder is characterised by a chronic and flaring course and is caused by a genetically predisposed, multifactorial process. A higher incidence is seen in people with fair skin and a positive family history. The characteristic rosacea symptoms manifest primarily, but not exclusively centrofacially, with forehead, nose, chin and cheeks significantly affected. Based on the various main symptoms a classification of the individual clinical pictures can be performed. However, a classification often does not reflect the clinical reality, since the various symptoms commonly coexist. The present review provides an introduction on pathogenesis and clinical manifestations of rosacea and prefers a symptom\u2010oriented therapy approach.<\/jats:p>","DOI":"10.1111\/ddg.13139","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T12:55:39Z","timestamp":1479732939000},"page":"4-15","source":"Crossref","is-referenced-by-count":39,"title":["Pathogenesis and clinical presentation of rosacea as a key for a symptom\u2010oriented therapy"],"prefix":"10.1111","volume":"14","author":[{"given":"M","family":"Reinholz","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology Ludwig Maximilian University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ruzicka","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Ludwig Maximilian University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Steinhoff","sequence":"additional","affiliation":[{"name":"Department of Dermatology and UCD Charles Institute for Translational Dermatology University College Dublin  Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Schaller","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Gieler","sequence":"additional","affiliation":[{"name":"Centre for Psychosomatic Medicine, Psychosomatic Dermatology University Hospital Gie\u00dfen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Sch\u00f6fer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Johann Wolfgang Goethe University  Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Homey","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Centre for Dermatology, Allergology and Dermatologic Surgery Helios Kliniken Wuppertal, Witten\/Herdecke University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TA","family":"Luger","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital M\u00fcnster  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,21]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11037.x"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10436.x"},{"key":"e_1_2_16_4_1","first-page":"419","article-title":"An epidemiological study of rosacea","volume":"69","author":"Berg M","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0856"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13556"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.05.018"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2007.50"},{"key":"e_1_2_16_9_1","first-page":"597","article-title":"Rosacea: 244 Tunisian cases","volume":"88","author":"Khaled A","year":"2010","journal-title":"Tunis Med"},{"key":"e_1_2_16_10_1","first-page":"60","article-title":"Rosacea in patients with skin of color: uncommon but not rare","volume":"86","author":"Alexis AF","year":"2010","journal-title":"Cutis"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30015-3"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00890-0"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00618.x"},{"key":"e_1_2_16_14_1","doi-asserted-by":"crossref","unstructured":"LewisV FinlayAY.10 years experience of the Dermatology Life Quality Index (DLQI). 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