{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:20:17Z","timestamp":1777594817270,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T00:00:00Z","timestamp":1487376000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Necrobiosis lipoidica ist eine seltene granulomat\u00f6se Erkrankung von bisher unzureichend gekl\u00e4rter \u00c4tiologie. H\u00e4ufig stellt die bei Diabetikern geh\u00e4uft zu beobachtende und zur Ulzeration neigende Dermatose eine starke Belastung f\u00fcr die Patienten dar. Bez\u00fcglich der Therapie existieren aktuell keine deutschen oder europ\u00e4ischen Leitlinien. Gleichzeitig l\u00e4sst sich unter der aktuellen Standardtherapie, der lokalen oder intral\u00e4sionalen Anwendung von Glukokortikoiden, nicht immer ein zufriedenstellendes Ansprechen beobachten. Daher wurde untersucht, ob seit dem Jahr 2000 publizierte Therapiemodalit\u00e4ten das Therapiespektrum relevant und erfolgversprechend erweitern. Es erfolgte eine Betrachtung aller Arbeiten im oben genannten Zeitraum, bei denen mehr als ein Einzelfallbericht je Therapiemodalit\u00e4t publiziert wurde. Insgesamt wurden in einem systematischen Review die Daten von 16 verschiedenen, seit 2000 publizierten Therapieverfahren in 49 Publikationen analysiert.<\/jats:p><jats:p>Im Ergebnis zeigte sich, dass die meisten Erfahrungen bez\u00fcglich der topischen PUVA\u2010Therapie, der photodynamischen Therapie (PDT) und der systemischen Therapie mit Fumars\u00e4ureestern vorliegen. Allerdings ist auff\u00e4llig, dass mit steigender Zahl der pro Behandlungsmodalit\u00e4t behandelten Patienten der Anteil der Patienten, bei denen eine Abheilung bzw. eine teilweise Abheilung berichtet wurde, sinkt. Wir interpretieren diese Beobachtung als Publikationsbias. Daher kann f\u00fcr keines der besprochenen Verfahren eine klare Empfehlung als Therapie der zweiten Wahl nach Versagen der lokalen bzw. intral\u00e4sionalen Steroidtherapie gegeben werden.<\/jats:p>","DOI":"10.1111\/ddg.13186_g","type":"journal-article","created":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T16:15:50Z","timestamp":1487434550000},"page":"151-158","source":"Crossref","is-referenced-by-count":4,"title":["Update: Therapie der Necrobiosis lipoidica"],"prefix":"10.1111","volume":"15","author":[{"given":"Melanie","family":"Peckruhn","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Hautkrankheiten Universit\u00e4tsklinikum Jena"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Tittelbach","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hautkrankheiten Universit\u00e4tsklinikum 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