{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:18:53Z","timestamp":1769836733337,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>MelaFind is a multispectral computer vision system intended to \u00adprovide additional information on melanocytic lesions suspected of being melanoma by \u00adobjectively assessing their three\u2010dimensional morphology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Analysis of the diagnostic performance of MelaFind in a real\u2010life clinical setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>In this observational study, 360 pigmented skin lesions (PSL) in 111 patients were assessed by office\u2010based dermatologists using MelaFind. Scores \u2265\u00a02 were considered to be suspicious of malignancy. The decision for surgical excision was left to the discretion of the examining dermatologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MelaFind scores \u2265\u00a02 were observed in 147 of 360 PSL (40.8\u00a0%). Of the 107 excised lesions with a MelaFind\u2010score \u2265\u00a02, the diagnosis of melanoma was made in three cases; 53 (49.5\u00a0%) lesions proved to be dysplastic nevi. Among all lesions biopsied (n = 113), the sensitivity and specificity of MelaFind was 100\u00a0% and 5.5\u00a0%, respectively. While a higher specificity of 68.5\u00a0% may be assumed with respect to the overall data set (n = 360), this assumption is limited by incomplete follow\u2010up data required to confirm that all non\u2010excised lesions with a score &lt;\u00a02 were actually benign.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The high sensitivity of MelaFind facilitated the detection of melanoma. The overall specificity and benign\u2010to\u2010malignant ratio of excised lesions were acceptable. These parameters may be improved by using higher cutoff scores for excisional biopsies, and by more vigorously selecting PSL for MelaFind examination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.13220","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T06:36:14Z","timestamp":1490337374000},"page":"414-419","source":"Crossref","is-referenced-by-count":15,"title":["Diagnostic performance of the MelaFind device in a real\u2010life clinical setting"],"prefix":"10.1111","volume":"15","author":[{"given":"Christine","family":"Fink","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology, and Allergology University Medical Center Ruprecht\u2010Karl University  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Jaeger","sequence":"additional","affiliation":[{"name":"Dermatology Practice  Heidelberg 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