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The International TSC Consensus Conference in 2012 provided guidelines for standardized baseline evaluation and follow\u2010up. Detailed clinical dermatological evaluation at the time of diagnosis and annual skin examination is recommended for both pediatric and adult populations. The onset of dermatological manifestations is clearly age\u2010related. However, dermatologists also have to assess for clinical manifestations beyond their own specialty. With advances in genetics and the advent of mTORC1 inhibitors, new specific therapeutic options have become available for TSC patients with skin manifestations. Early intervention is commonly recommended for symptomatic, rapidly evolving, disfiguring, or debilitating lesions. The consensus guidelines recommend \u201ctreatment as appropriate for the lesion and clinical context\u201d and suggest the use of surgical excision, laser therapy, or topical mTORC1 inhibitors. Topical mTORC1 inhibitors present a useful option for TSC\u2010associated skin lesions, particularly in medically complex patients. They may prevent or reduce the risks of subsequent surgeries and permanent scarring.<\/jats:p>","DOI":"10.1111\/ddg.13264","type":"journal-article","created":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T13:36:48Z","timestamp":1497015408000},"page":"695-700","source":"Crossref","is-referenced-by-count":15,"title":["Dermatological manifestations of tuberous sclerosis complex (TSC)"],"prefix":"10.1111","volume":"15","author":[{"given":"Daniel","family":"Ebrahimi\u2010Fakhari","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Neonatology, Saarland Tuberous Sclerosis Center Saarland University Medical Center  Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, Saarland Tuberous Sclerosis Center Saarland University Medical Center  Homburg\/Saar 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