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In contrast to circumscribed lipomas, they develop diffusely and symmetrically and are not surrounded by a fibrous pseudocapsule.<\/jats:p><jats:p>The most common form is benign symmetric lipomatosis (BSL; Launois\u2010Bensaude syndrome), of which four types are distinguished based on the distribution pattern of hyperplastic adipose tissue. The etiology and pathogenesis of the disease are still largely unknown, although some forms appear to have a hereditary basis or to be associated with increased alcohol consumption. In some cases, mitochondrial dysfunctions have been detected. Lipomatoses may be solitary, but may also be associated with other symptoms or illnesses (comorbidity). Effective drug therapies are not known, but surgical procedures can alleviate the symptoms.<\/jats:p><jats:p>Lipomatosis dolorosa, which can be distinguished from BSL, occurs predominantly in middle\u2010aged women and is characterized by proliferation of adipose tissue and severe pain in the affected areas. Various differential diagnoses and concomitant illnesses need to be considered, in particular depression. There are no evidence\u2010based recommendations for therapy. Repetitive lidocaine infusions can achieve temporary improvement. Recurrence after surgical intervention is not uncommon, but long\u2010term success is also possible.<\/jats:p>","DOI":"10.1111\/ddg.13460","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T13:55:26Z","timestamp":1518443726000},"page":"313-327","source":"Crossref","is-referenced-by-count":7,"title":["Lipomatoses"],"prefix":"10.1111","volume":"16","author":[{"given":"Philipp","family":"Al Ghazal","sequence":"first","affiliation":[{"name":"Department of Dermatology Venerology and Allergology University Medical Center  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa\u2010Lena","family":"Gr\u00f6nemeyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venerology and Allergology University Medical Center  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venerology and Allergology University Medical Center  G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology (NIB) University Medical Center G\u00f6ttingen and University of Osnabr\u00fcck  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"275","volume-title":"Lectures illustrative of various subjects in pathology and surgery","author":"Brodie BC","year":"1846"},{"key":"e_1_2_6_3_1","first-page":"106","article-title":"\u00dcber den Fetthals","volume":"37","author":"Madelung OW.","year":"1888","journal-title":"Langenbecks Archiv Klin Chirurg"},{"key":"e_1_2_6_4_1","first-page":"289","article-title":"L'ad\u00e9nolipomatose symmetrique","volume":"1","author":"Launois P","year":"1898","journal-title":"Bull Soc m\u00e9d Hop Paris"},{"key":"e_1_2_6_5_1","first-page":"160","article-title":"Case report of comorbid alcohol\u2010induced psychotic disorder and Madelung's disease","volume":"26","author":"Sun Z","year":"2014","journal-title":"Shanghai Arch Psychiatry"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-012-9874-5"},{"key":"e_1_2_6_7_1","first-page":"1753","article-title":"Benign symmetric lipomatosis\u2013symptom of alcoholic liver disease","volume":"107","author":"St\u00e4helin HB","year":"1977","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_6_8_1","first-page":"33","article-title":"Benign symmetrical lipomatosis in women. 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