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Im Gegensatz zu umschriebenen Lipomen entwickeln sie sich meist diffus\u2010symmetrisch und sind nicht von einer fibr\u00f6sen Pseudokapsel umgeben.<\/jats:p><jats:p>Am h\u00e4ufigsten ist die benigne symmetrische Lipomatose (BSL; Launois\u2010Bensaude\u2010Syndrom), von der aufgrund des Verteilungsmusters des hyperplastischen Fettgewebes vier Typen unterschieden werden. \u00c4tiologie und Pathogenese der Erkrankung sind noch weitgehend unbekannt, wobei manche Formen eine heredit\u00e4re Basis zu haben oder mit vermehrtem Alkoholkonsum assoziiert zu sein scheinen. In einigen F\u00e4llen wurden mitochondriale Fehlfunktionen nachgewiesen. Lipomatosen k\u00f6nnen isoliert, aber auch mit Begleitsymptomen oder \u2010erkrankungen (Komorbidit\u00e4t) vergesellschaftet auftreten. Wirksame medikament\u00f6se Therapien sind nicht bekannt; chirurgische Verfahren k\u00f6nnen hingegen zur Besserung der Symptome f\u00fchren.<\/jats:p><jats:p>Die von der BSL abzugrenzende Lipomatosis dolorosa tritt bevorzugt bei Frauen mittleren Alters auf und ist durch Vermehrung des Fettgewebes sowie starke Schmerzen in den betroffenen Bereichen gekennzeichnet. Verschiedene Differenzialdiagnosen und Begleiterkrankungen sind abzukl\u00e4ren, insbesondere Depressionen. Evidenzbasierte Therapieempfehlungen existieren nicht. Repetitive Lidocain\u2010Infusionen k\u00f6nnen tempor\u00e4re Besserungen bewirken; nach chirurgischen Interventionen treten h\u00e4ufig Rezidive auf, allerdings werden auch langfristige Erfolge erzielt.<\/jats:p>","DOI":"10.1111\/ddg.13460_g","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T11:05:22Z","timestamp":1521025522000},"page":"313-328","source":"Crossref","is-referenced-by-count":1,"title":["Lipomatosen"],"prefix":"10.1111","volume":"16","author":[{"given":"Philipp","family":"Al Ghazal","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie Universit\u00e4tsmedizin G\u00f6ttingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa\u2010Lena","family":"Gr\u00f6nemeyer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie Universit\u00e4tsmedizin G\u00f6ttingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie Universit\u00e4tsmedizin G\u00f6ttingen"},{"name":"Nieders\u00e4chsisches Institut f\u00fcr Berufsdermatologie (NIB) Universit\u00e4tsmedizin G\u00f6ttingen und Universit\u00e4t Osnabr\u00fcck"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"275","volume-title":"Lectures illustrative of various subjects in pathology and surgery","author":"Brodie BC","year":"1846"},{"key":"e_1_2_8_3_1","first-page":"106","article-title":"\u00dcber den Fetthals","volume":"37","author":"Madelung OW.","year":"1888","journal-title":"Langenbecks Archiv Klin Chirurg"},{"key":"e_1_2_8_4_1","first-page":"289","article-title":"L'ad\u00e9nolipomatose symmetrique","volume":"1","author":"Launois P","year":"1898","journal-title":"Bull Soc m\u00e9d Hop Paris"},{"key":"e_1_2_8_5_1","first-page":"160","article-title":"Case report of comorbid alcohol\u2010induced psychotic disorder and Madelung's disease","volume":"26","author":"Sun Z","year":"2014","journal-title":"Shanghai Arch Psychiatry"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-012-9874-5"},{"key":"e_1_2_8_7_1","first-page":"1753","article-title":"Benign symmetric lipomatosis\u2013symptom of alcoholic liver disease","volume":"107","author":"St\u00e4helin HB","year":"1977","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_8_8_1","first-page":"33","article-title":"Benign symmetrical lipomatosis in women. 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