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Conventional chemotherapy has been superseded by novel first\u2010line therapies, including systemic immunotherapies (anti\u2010CTLA4 and anti\u2010PD1; authorization of anti\u2010PDL1 is anticipated) and therapies targeting specific mutations (<jats:italic>BRAF, NRAS,<\/jats:italic> and <jats:italic>c\u2010KIT<\/jats:italic>). Thus, treating physicians are confronted with new challenges, such as stratifying patients for appropriate treatments and monitoring long\u2010term responders for progression. Consequently, reliable methods for monitoring disease progression or treatment resistance are necessary.<\/jats:p><jats:p>Localized and advanced cancers may generate circulating tumor cells and circulating tumor DNA (ctDNA) that can be detected and quantified from peripheral blood samples (liquid biopsy). For melanoma patients, liquid biopsy results may be useful as novel predictive biomarkers to guide therapeutic decisions, particularly in the context of mutation\u2010based targeted therapies. The challenges of using liquid biopsy include strict criteria for the phenotypic nature of circulating MM cells or their fragments and the instability of ctDNA in blood. The limitations of liquid biopsy in routine diagnostic testing are discussed in this review.<\/jats:p>","DOI":"10.1111\/ddg.13461","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T13:18:49Z","timestamp":1520428729000},"page":"405-414","source":"Crossref","is-referenced-by-count":14,"title":["Liquid biopsy to monitor melanoma patients"],"prefix":"10.1111","volume":"16","author":[{"given":"Maria Rita","family":"Gaiser","sequence":"first","affiliation":[{"name":"Skin Cancer Unit German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Department of Dermatology Venereology and Allergology University Medical Center Mannheim Ruprecht\u2010Karl University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolas","family":"von Bubnoff","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology and Stem Cell Transplantation Medical Center University of Freiburg  Germany"},{"name":"German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoffer","family":"Gebhardt","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Department of Dermatology Venereology and Allergology University Medical Center Mannheim Ruprecht\u2010Karl University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen Sven","family":"Utikal","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Department of Dermatology Venereology and Allergology University Medical Center Mannheim Ruprecht\u2010Karl University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_8_3_1","volume-title":"GLOBOCAN 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012. 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